CAJ | 학술논문

目的：探讨40～70岁年龄段正常汉族人颅脑各区域磁共振表观弥散系数（ADC）变化特点，建立正常中老年人群颅脑ADC值变化趋势的基准。方法选择30例无阳性颅脑病征的正常汉族受试者，按年龄段分为3组，使用GE Medical System 3.0 T超导磁共振扫描仪进行头部平扫及弥散加权成像，测量额叶灰质、白质、壳核、丘脑及小脑感兴趣区ADC值，分析各年龄组不同区域脑组织ADC值的关系。结果同一年龄的正常中老年人不同部位的脑组织ADC值不同，其中以额叶灰质最高，其次为壳核、额叶白质与丘脑，小脑最低（均P＜0.05）。不同部位脑组织左右两侧间ADC值均无统计学差异（均P＞0.05）。不同年龄段的正常中老年人额叶灰质、额叶白质、壳核、丘脑与小脑ADC值间均无统计学差异（均P＞0.05）；不同部位脑组织的ADC值随着年龄的增长均呈上升趋势，且40~60岁上升趋势较缓，60岁之后除小脑外，额叶灰质、额叶白质、壳核、丘脑上升趋势加快。结论正常中老年人群同一部位脑组织的ADC值随年龄增长而上升，60岁之后总体上升趋势加快。
목적：탐토40～70세년령단정상한족인로뇌각구역자공진표관미산계수（ADC）변화특점，건립정상중노년인군로뇌ADC치변화추세적기준。방법선택30례무양성로뇌병정적정상한족수시자，안년령단분위3조，사용GE Medical System 3.0 T초도자공진소묘의진행두부평소급미산가권성상，측량액협회질、백질、각핵、구뇌급소뇌감흥취구ADC치，분석각년령조불동구역뇌조직ADC치적관계。결과동일년령적정상중노년인불동부위적뇌조직ADC치불동，기중이액협회질최고，기차위각핵、액협백질여구뇌，소뇌최저（균P＜0.05）。불동부위뇌조직좌우량측간ADC치균무통계학차이（균P＞0.05）。불동년령단적정상중노년인액협회질、액협백질、각핵、구뇌여소뇌ADC치간균무통계학차이（균P＞0.05）；불동부위뇌조직적ADC치수착년령적증장균정상승추세，차40~60세상승추세교완，60세지후제소뇌외，액협회질、액협백질、각핵、구뇌상승추세가쾌。결론정상중노년인군동일부위뇌조직적ADC치수년령증장이상승，60세지후총체상승추세가쾌。
Objective To investigate the variability and trends of apparent diffusion coefficient (ADC) of different brain segments in normal middle- aged and aged Han adults. Methods Thirty Han normal adult subjects aged 40~70 without positive cerebral symptoms were divided into 3 age groups (40~49, 50~59, 60~70). Plain scan and diffusion weighted imaging (DWI) were performed by 3.0T MR in al subjects. The images were transferred to ADW 4.3 workstations for post- processing. Regions of interest were placed covering grey and white matter of frontal lobe, putamen, thalamus and cerebel um. The relationship of ADC value with different ages and cerebral regions was analyzed. Results The cerebral tissues of different location had differ-ent values in the same age group. The highest ADC value was detected in gray matter of the frontal lobe, fol owed by putamen, white matter of frontal lobe and the thalamus, and the lowest one was in cerebel um. There was no significant difference in ADCs between two sides of the same cerebral parts of different regions.(P>0.05).Although there was no significant difference in ADCs between grey and white matter of frontal lobe, putamen, thalamus and cerebel um of different age groups, the ADC value of the same region tended to increase with age. The changes of ADC value in subjects aged 40~60 presented a much slower rate and an upshift tendency was observed in subjects aged>60. Conclusion The ADC value of the same region in middle- aged and elderly people tended to increase with the age, particularly in subjects aged>60 years.