CAJ | 학술논문

目的：研究急性脑梗死后血清血小板衍生内皮细胞生长因子浓度（PD- ECGF）变化与神经功能缺损的关系。方法测定60例脑梗死患者发病后24h内、第3天、第7天、第14天的PD- ECGF浓度，同步评估美国国立卫生研究院脑卒中量表（NIHSS）评分，并记录脑梗死的体积。结果脑梗死患者发病后24h内、第3天、第7天、第14天的平均血清PD- ECGF浓度分别为（4080.62±1569.27）、（4386.03±1746.05）、（5473.24±2312.75）、（3365.72±1421.76）pg/ml，4个时点间的差异有统计学意义（F=14.297，P＜0.05），并均高于对照组（2687.92±950.60）pg/ml。相应时点的NIHSS评分分别为（6.35±4.09）、（6.25±4.45）、（5.42±4.44）、（4.68±4.49）分，4个时点间的差异无统计学意义（F=1.925，P＞0.05）。发病后第3天脑梗死体积与血清PD- ECGF浓度无相关性（r=0.107，P＞0.05），但与NIHSS评分具有相关性（r=0.619，P＜0.05）。结论血清PD- ECGF浓度在脑梗死后即有升高，但浓度的高低与神经功能缺损程度和康复无关，与急性脑梗死的病理生理过程相一致。
목적：연구급성뇌경사후혈청혈소판연생내피세포생장인자농도（PD- ECGF）변화여신경공능결손적관계。방법측정60례뇌경사환자발병후24h내、제3천、제7천、제14천적PD- ECGF농도，동보평고미국국립위생연구원뇌졸중량표（NIHSS）평분，병기록뇌경사적체적。결과뇌경사환자발병후24h내、제3천、제7천、제14천적평균혈청PD- ECGF농도분별위（4080.62±1569.27）、（4386.03±1746.05）、（5473.24±2312.75）、（3365.72±1421.76）pg/ml，4개시점간적차이유통계학의의（F=14.297，P＜0.05），병균고우대조조（2687.92±950.60）pg/ml。상응시점적NIHSS평분분별위（6.35±4.09）、（6.25±4.45）、（5.42±4.44）、（4.68±4.49）분，4개시점간적차이무통계학의의（F=1.925，P＞0.05）。발병후제3천뇌경사체적여혈청PD- ECGF농도무상관성（r=0.107，P＞0.05），단여NIHSS평분구유상관성（r=0.619，P＜0.05）。결론혈청PD- ECGF농도재뇌경사후즉유승고，단농도적고저여신경공능결손정도화강복무관，여급성뇌경사적병리생리과정상일치。
Objective To investigate serum concentrations of platelet derived- endothelial cellgrowth factor (PD- ECGF) in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were included. Serum concentra-tions of PD- ECGF and scores of National Institutes of Health Stroke Scale (NIHSS) were measured at 24h and d3, 7, 14 after the onset of stroke;and the volume of infarction were also documented. Results The mean values of serum PD- ECGF concentrations at 24 hours and d3, 7, 14 after onset were 4 080.62±1 569.27pg/ml, 4 386.03±1 746.05pg/ml, 5 473.24±2 312.75pg/ml and 3 365.72±1 421.76pg/ml, respectively(F=14.297, P<0.05), which were al higher than that of controls(2 687.92±950.60pg/ml, P<0.05). NIHSS scores at the corresponding time points were 6.35 ±4.09, 6.25 ±4.45, 5.42 ±4.44 and 4.68 ±4.49, respectively (F=1.925, P>0.05). The serum PD- ECGF concentrations were not correlated with cerebral infarction volumes(r=0.107, P>0.05), but the cerebral infarction volume on d3 after the onset was correlated with NIHSS score (r=0.619, P<0.05). Conclusion The serum concentrations of PD- ECGF begin to rise after occurrence of infarction, which are consistent with the pathophysiological process of acute cerebral infarction, but not correlated with the degree of neurological impairment or rehabilitation.