CAJ | 학술논문

目的：探讨血浆D-二聚体测定对深静脉血栓形成（DVT）诊断和疗效评估的意义及DVT患者临床危险因素。方法回顾性分析435例DVT患者的血浆D-二聚体水平，同时在体检人群中随机选择150例作为对照组，比较分析DVT患者中135例初诊时的危险因素。进一步监测其中的33例DVT患者治疗后1~3d、7~10d、15d的血浆D-二聚体变化情况。结果 DVT患者血浆D-二聚体水平与对照组相比有统计学差异（P=0.000），抗凝治疗的有效率为78.8%。治疗有效组DVT患者的血浆D-二聚体下降程度与无效组相比有统计学差异（P=0.005）。年龄＜40岁的DVT患者中手术和外伤是主要危险因素，而年龄≥40岁患者中肿瘤、内科疾病、中心静脉置管及长期卧床是其主要危险因素。结论血浆D-二聚体是DVT诊断及疗效评估的重要指标，DVT危险因素是其一级预防的依据。
목적：탐토혈장D-이취체측정대심정맥혈전형성（DVT）진단화료효평고적의의급DVT환자림상위험인소。방법회고성분석435례DVT환자적혈장D-이취체수평，동시재체검인군중수궤선택150례작위대조조，비교분석DVT환자중135례초진시적위험인소。진일보감측기중적33례DVT환자치료후1~3d、7~10d、15d적혈장D-이취체변화정황。결과 DVT환자혈장D-이취체수평여대조조상비유통계학차이（P=0.000），항응치료적유효솔위78.8%。치료유효조DVT환자적혈장D-이취체하강정도여무효조상비유통계학차이（P=0.005）。년령＜40세적DVT환자중수술화외상시주요위험인소，이년령≥40세환자중종류、내과질병、중심정맥치관급장기와상시기주요위험인소。결론혈장D-이취체시DVT진단급료효평고적중요지표，DVT위험인소시기일급예방적의거。
Objective To investigate plasma D- dimer levels in patients with deep venous thrombosis (DVT). Methods Plasma D- dimer levels were measured in 435 patients with DVT, and 150 healthy subjects (controls). The clinical data and plas-ma D- dimer levels were retrospectively analyzed in 135 DVT patients and the D- dimer levels were monitored in 33 DVT patients during the anticoagulation therapy at different time points (at 1~3d, 7~10d and 15d). Results Compared to healthy subjects, plasma D- dimer levels in DVT patients were significantly increased (P=0.000). The overal effective rate of treatment was 78.8%, D- dimer levels in effective patientws was significantly decreased after treatment (P=0.005). For patients aged<40, surgery and trauma were major risk factors of DVT;for those aged≥40, medical diseases, cancer, placement of central venous catheter and long- term bed rest were major risk factors. Conclusion Measurement of plasma D- dimer levels is of value in diagnosis and monotoring of therapeutic effect for patients with deep vein thrombosis.