药品评价
藥品評價
약품평개
DRUG REEVALUATION
2013年
22期
28-29,46
,共3页
婴幼儿%布拉氏酵母菌散剂%抗生素相关性腹泻
嬰幼兒%佈拉氏酵母菌散劑%抗生素相關性腹瀉
영유인%포랍씨효모균산제%항생소상관성복사
Infants and Young Children%Boulardii%Antibiotic-associated Diarrhea
目的：观察布拉氏酵母菌散剂预防及治疗婴幼儿抗生素相关性腹泻的临床疗效。方法：将180例患儿随机分成对照组和预防组各90例，预防组在使用抗生素时即开始口服布拉氏酵母菌，对照组使用抗生素仅在出现腹泻后加服布拉氏酵母菌，两组病例发生腹泻后均加用双八面体蒙脱石散剂口服，重型腹泻者给予补液、补充电解质、纠正酸中毒等对症治疗。观察两组腹泻的发生率及临床疗效。结果：预防组继发腹泻19例，发病率为21.11%，对照组继发腹泻34例，发病率为37.78%；预防组治疗总有效率94.73%，对照组总有效率70.58%，两组患儿在腹泻发生率、腹泻治疗的疗效的比较其差异具有统计学意义(P<0.05)。结论：使用抗生素同时加服布拉氏酵母菌，可降低抗生素相关性腹泻的发生率，提高治愈率。
目的：觀察佈拉氏酵母菌散劑預防及治療嬰幼兒抗生素相關性腹瀉的臨床療效。方法：將180例患兒隨機分成對照組和預防組各90例，預防組在使用抗生素時即開始口服佈拉氏酵母菌，對照組使用抗生素僅在齣現腹瀉後加服佈拉氏酵母菌，兩組病例髮生腹瀉後均加用雙八麵體矇脫石散劑口服，重型腹瀉者給予補液、補充電解質、糾正痠中毒等對癥治療。觀察兩組腹瀉的髮生率及臨床療效。結果：預防組繼髮腹瀉19例，髮病率為21.11%，對照組繼髮腹瀉34例，髮病率為37.78%；預防組治療總有效率94.73%，對照組總有效率70.58%，兩組患兒在腹瀉髮生率、腹瀉治療的療效的比較其差異具有統計學意義(P<0.05)。結論：使用抗生素同時加服佈拉氏酵母菌，可降低抗生素相關性腹瀉的髮生率，提高治愈率。
목적：관찰포랍씨효모균산제예방급치료영유인항생소상관성복사적림상료효。방법：장180례환인수궤분성대조조화예방조각90례，예방조재사용항생소시즉개시구복포랍씨효모균，대조조사용항생소부재출현복사후가복포랍씨효모균，량조병례발생복사후균가용쌍팔면체몽탈석산제구복，중형복사자급여보액、보충전해질、규정산중독등대증치료。관찰량조복사적발생솔급림상료효。결과：예방조계발복사19례，발병솔위21.11%，대조조계발복사34례，발병솔위37.78%；예방조치료총유효솔94.73%，대조조총유효솔70.58%，량조환인재복사발생솔、복사치료적료효적비교기차이구유통계학의의(P<0.05)。결론：사용항생소동시가복포랍씨효모균，가강저항생소상관성복사적발생솔，제고치유솔。
Objective: To observe the clinical effect of Boulardii in the prevention and treatment of antibiotic-associated diarrhea in infants and young children. Methods:180 patients were randomly divided into control group and prevention group with 90 cases in each group. Boulardii was administered to the children before antibiotic therapy (prevention), the other 90 children were given Boulardii after diarrhea appeared. The incidence rate of antibiotic-associated diarrhea was compared in the two groups. Result:The incidence rate of diarrhea was 21.11%in the prevention group and 37.78%in the control. The overall response rate was 94.73%in the prevention group and 70.58%in the control group. There was significant difference between the two groups (P<0.05). Conclusion:The use of Boulardii could prevent antibiotic-associated diarrhea and improve the cure rate.
