中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
5期
761-762
,共2页
邹良能%杨嘉勇%林明华%蔡加锭%翁建光
鄒良能%楊嘉勇%林明華%蔡加錠%翁建光
추량능%양가용%림명화%채가정%옹건광
耐药%肺结核%免疫调节
耐藥%肺結覈%免疫調節
내약%폐결핵%면역조절
Drug resistance%Pulmonary uberculosis%immunomodulatory
目的：评价免疫调节在治疗MDR-TB中的临床作用。方法：采用随机配对分组法将68例耐多药肺结核患者分为治疗组和对照组。两组应用相同的二线抗痨方案治疗组加用免疫调节剂母牛分枝杆菌菌苗6个月，总疗程24个月。结果：疗程结束后，治疗组痰菌阴转率77.1%，对照组63.6%，痰菌阴转率治疗组显著高于对照组(P<0·05)。治疗组病灶吸收，空洞闭合程度均显著高于对照组(P<0.05)。结论：治疗组的治疗效果明显优于对照组，认为化学药物联合免疫调节剂是提高治疗MDR-TB疗效的有效措施。
目的：評價免疫調節在治療MDR-TB中的臨床作用。方法：採用隨機配對分組法將68例耐多藥肺結覈患者分為治療組和對照組。兩組應用相同的二線抗癆方案治療組加用免疫調節劑母牛分枝桿菌菌苗6箇月，總療程24箇月。結果：療程結束後，治療組痰菌陰轉率77.1%，對照組63.6%，痰菌陰轉率治療組顯著高于對照組(P<0·05)。治療組病竈吸收，空洞閉閤程度均顯著高于對照組(P<0.05)。結論：治療組的治療效果明顯優于對照組，認為化學藥物聯閤免疫調節劑是提高治療MDR-TB療效的有效措施。
목적：평개면역조절재치료MDR-TB중적림상작용。방법：채용수궤배대분조법장68례내다약폐결핵환자분위치료조화대조조。량조응용상동적이선항로방안치료조가용면역조절제모우분지간균균묘6개월，총료정24개월。결과：료정결속후，치료조담균음전솔77.1%，대조조63.6%，담균음전솔치료조현저고우대조조(P<0·05)。치료조병조흡수，공동폐합정도균현저고우대조조(P<0.05)。결론：치료조적치료효과명현우우대조조，인위화학약물연합면역조절제시제고치료MDR-TB료효적유효조시。
Objective:Evaluation immunomodulatory role in the clinical treatment of MDR-TB. Methods:68 cases of multidrug-resistant tuberculosis patients are divided into treatment group and control group by random pair group method with a total course of 24 months. Two groups apply the same second-line anti-tuberculosis program, as wel as the treatment group with additional immunomodulator Mycobacterium vaccae vaccine 6 months. Results:After the end of treatment, the sputum conversion rate in the treatment group is 77.1%, and 63.6% in the control group. The sputum conversion rate in the treatment group is significantly higher than the control group (P<0·05). Lesion absorption and cavity closure in the treatment group is obviously higher than control group (P<0·05). Conclusion:Based on the therapeutic effect in the treatment group is bet er than the control group, it is concluded that the chemical drug combination immunomodulator is effective measure to improve the efficacy of the treatment of MDR-TB
