中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
6期
497-499
,共3页
吴盛各%刘秀峰%李铺%邓燕玲
吳盛各%劉秀峰%李鋪%鄧燕玲
오성각%류수봉%리포%산연령
卒中后抑郁%抑郁症%细胞因子%超敏C反应蛋白
卒中後抑鬱%抑鬱癥%細胞因子%超敏C反應蛋白
졸중후억욱%억욱증%세포인자%초민C반응단백
Post-stroke depression%Depression%Cytokines%hs-CRP
目的 比较卒中后抑郁与抑郁症患者多种血清细胞因子表达及超敏C反应蛋白水平,进一步探讨其发病机制.方法 采用酶联免疫吸附法(ELISA)检测30例卒中后抑郁病人(卒中后抑郁组)、30例卒中后非抑郁病人(卒中非抑郁组)、30例抑郁症病人(抑郁症组)、30例健康人(正常对照组)的血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,同时采用散射比浊法测定4组患者的血清超敏C反应蛋白(hs-CRP)水平.结果 卒中后抑郁组、抑郁症组、卒中非抑郁组及正常对照组的血清IL-1β,IL-6,TNF-α和hs-CRP水平分别为:[(137.23±8.12)pg/ml,(34.12±3.12) pg/ml,(64.62±6.11) pg/ml,(6.70± 1.52) mg/L];[(133.21 ±7.56) pg/ml,(33.56±2.65) pg/ml,(62.95±5.66) pg/ml,(1.65±0.99) mg/L];[(43.25±6.23) pg/ml,(16.12±2.60) pg/ml,(32.23±7.12) pg/ml,(5.77± 1.21) mg/L];[(42.12±5.78) pg/ml,(15.32±3.23) pg/ml,(31.55±6.70) pg/ml,(0.66±0.74) mg/L].卒中后抑郁组和抑郁症组的血清IL-1β,IL-6,TNF-α水平明显高于卒中非抑郁组和正常对照组,差异有统计学意义(P＜0.01);血清hs-CRP水平:卒中后抑郁组＞卒中非抑郁组＞抑郁症组＞正常对照组,差异有统计学意义(P＜0.05).结论 卒中后抑郁和抑郁症可能具有相同的免疫机制.
目的 比較卒中後抑鬱與抑鬱癥患者多種血清細胞因子錶達及超敏C反應蛋白水平,進一步探討其髮病機製.方法 採用酶聯免疫吸附法(ELISA)檢測30例卒中後抑鬱病人(卒中後抑鬱組)、30例卒中後非抑鬱病人(卒中非抑鬱組)、30例抑鬱癥病人(抑鬱癥組)、30例健康人(正常對照組)的血清白細胞介素-1β(IL-1β)、白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)水平,同時採用散射比濁法測定4組患者的血清超敏C反應蛋白(hs-CRP)水平.結果 卒中後抑鬱組、抑鬱癥組、卒中非抑鬱組及正常對照組的血清IL-1β,IL-6,TNF-α和hs-CRP水平分彆為:[(137.23±8.12)pg/ml,(34.12±3.12) pg/ml,(64.62±6.11) pg/ml,(6.70± 1.52) mg/L];[(133.21 ±7.56) pg/ml,(33.56±2.65) pg/ml,(62.95±5.66) pg/ml,(1.65±0.99) mg/L];[(43.25±6.23) pg/ml,(16.12±2.60) pg/ml,(32.23±7.12) pg/ml,(5.77± 1.21) mg/L];[(42.12±5.78) pg/ml,(15.32±3.23) pg/ml,(31.55±6.70) pg/ml,(0.66±0.74) mg/L].卒中後抑鬱組和抑鬱癥組的血清IL-1β,IL-6,TNF-α水平明顯高于卒中非抑鬱組和正常對照組,差異有統計學意義(P＜0.01);血清hs-CRP水平:卒中後抑鬱組＞卒中非抑鬱組＞抑鬱癥組＞正常對照組,差異有統計學意義(P＜0.05).結論 卒中後抑鬱和抑鬱癥可能具有相同的免疫機製.
목적 비교졸중후억욱여억욱증환자다충혈청세포인자표체급초민C반응단백수평,진일보탐토기발병궤제.방법 채용매련면역흡부법(ELISA)검측30례졸중후억욱병인(졸중후억욱조)、30례졸중후비억욱병인(졸중비억욱조)、30례억욱증병인(억욱증조)、30례건강인(정상대조조)적혈청백세포개소-1β(IL-1β)、백세포개소-6(IL-6)、종류배사인자-α(TNF-α)수평,동시채용산사비탁법측정4조환자적혈청초민C반응단백(hs-CRP)수평.결과 졸중후억욱조、억욱증조、졸중비억욱조급정상대조조적혈청IL-1β,IL-6,TNF-α화hs-CRP수평분별위:[(137.23±8.12)pg/ml,(34.12±3.12) pg/ml,(64.62±6.11) pg/ml,(6.70± 1.52) mg/L];[(133.21 ±7.56) pg/ml,(33.56±2.65) pg/ml,(62.95±5.66) pg/ml,(1.65±0.99) mg/L];[(43.25±6.23) pg/ml,(16.12±2.60) pg/ml,(32.23±7.12) pg/ml,(5.77± 1.21) mg/L];[(42.12±5.78) pg/ml,(15.32±3.23) pg/ml,(31.55±6.70) pg/ml,(0.66±0.74) mg/L].졸중후억욱조화억욱증조적혈청IL-1β,IL-6,TNF-α수평명현고우졸중비억욱조화정상대조조,차이유통계학의의(P＜0.01);혈청hs-CRP수평:졸중후억욱조＞졸중비억욱조＞억욱증조＞정상대조조,차이유통계학의의(P＜0.05).결론 졸중후억욱화억욱증가능구유상동적면역궤제.
Objective To compare the serum cytokines and high-sensitive C-reactive protein (hs-CRP) in the post-stroke depression(PSD) and depression patients,and further study of the pathogenesis PSD and depression.Methods The levels of serum IL-1β,IL-6 and TNF-α in the PSD group(n=30),the depression group(n=30),the post-stroke non-depression group(n=30)and normal control group(n=30)were measured with enzymatic-linked immunosorbent assay(ELISA),and the levels of serum hs-CRP were measured by scatter rate nephelometryat for these four groups.Results The levels of serum IL-1β,IL-6,TNF-α and hs-CRP in the PSD group,the depression group,the the post-stroke non-depression group and the normal control group were respectively((137.23 ±8.12) pg/ml,(34.12±3.12) pg/ml,(64.62±6.11) pg/ml,(15.36±6.25) mg/L) ; ((133.21 ±7.56) pg/ml,(33.56±2.65) pg/ml,(62.95±5.66) pg/ml,(4.02± 1.21) mg/L) ; ((43.25 ±6.23) pg/ml,(16.12±2.60) pg/ml,(32.23±7.12) pg/ml,(14.88±7.23) mg/L) ; ((42.12±5.78) pg/ml,(15.32±3.23) pg/ml,(31.55±6.70) pg/ml,(3.68± 1.11)mg/L).The levels of serum IL-1β,IL-6 and TNF-αt in the PSD group and the depression group increased significantly than those in the the post-stroke non-depression group and the normal control group(P＜0.01).The levels of serum hs-CRP:PSD group ＞ post-stroke non-depression group ＞ depression group ＞ normal control group(P＜0.05).Conclusion The PSD and depression may have the same immune mechanism.
