CAJ | 학술논문

通过稳态荧光探针法、激光光散射法等研究了苄氧基封端的甲基丙烯酸-2-(二甲氨基)乙酯和甲基丙烯酸甲酯的两亲性嵌段聚合物 BzO-PDMAE-MA30-PMMA10在水溶液中的胶束化行为。实验结果表明该共聚物具有明显的 pH 值和温度响应性。使用憎水性药物萘普生和亲水性药物维生素 C,制备胶束-药物体系,采用紫外分光光度法考查该体系在药物控制释放方面的应用。体外释放实验表明药物释放体系随pH 值降低可以加快药物释放,温度升高而致使释放变快。药物释放体系无突释现象,且具有 pH 值和温度响应性。
통과은태형광탐침법、격광광산사법등연구료변양기봉단적갑기병희산-2-(이갑안기)을지화갑기병희산갑지적량친성감단취합물 BzO-PDMAE-MA30-PMMA10재수용액중적효속화행위。실험결과표명해공취물구유명현적 pH 치화온도향응성。사용증수성약물내보생화친수성약물유생소 C,제비효속-약물체계,채용자외분광광도법고사해체계재약물공제석방방면적응용。체외석방실험표명약물석방체계수pH 치강저가이가쾌약물석방,온도승고이치사석방변쾌。약물석방체계무돌석현상,차구유 pH 치화온도향응성。
The micellization behavior of the diblock copolymer BzO-PDMAEMA30-b-PMMA10 in aqueous solution were investigated by the measurements of fluorescence probe techniques and laser light scattering studies.Using naproxen as model hydrophobic drugs and using vitamin C as model hydrophilic drugs,the application of amphiphilic polymer on controlled-release drug delivery systems were investigated by UV-visible spectrophotometer. The results demonstrated that the release rate of naproxen from polymer micelles were significantly faster drug release by reducing of pH values.Furthermore,the release rate run faster by increasing of temperature. Any initial burst release was not observed in the experiments.The drug-controlled release showed pH-responsive and thermoresponsive.