CAJ | 학술논문

免疫抑制药对预防急性排斥反应是卓有成效的，但是不同患者的临床用药有着很大的药动学和药效学差异。遗传变异对人与人之间药物处置、药效以及毒性差异的影响是近年来该领域研究的重点。本文系统地地概述了现阶段已用于临床或处于临床研究阶段的免疫抑制剂与人体相关基因多态性的关系，包括与免疫抑制药药物药动学和药效学相关的酶的基因多态性、供体基因多态性、药物作用靶位基因多态性。本文综述了该领域研究的现状与进展。
면역억제약대예방급성배척반응시탁유성효적，단시불동환자적림상용약유착흔대적약동학화약효학차이。유전변이대인여인지간약물처치、약효이급독성차이적영향시근년래해영역연구적중점。본문계통지지개술료현계단이용우림상혹처우림상연구계단적면역억제제여인체상관기인다태성적관계，포괄여면역억제약약물약동학화약효학상관적매적기인다태성、공체기인다태성、약물작용파위기인다태성。본문종술료해영역연구적현상여진전。
Immunosuppressive drugs used in organ transplantation are highly effective in preventing acute rejection. However,the clinical use of the drugs is complicated by the fact that they display highly variable pharmacokinetics and pharmacodynamics among in-dividual patients. The influence of genetic variation on the interindividual variability in immunosuppressive drug disposition,efficacy and toxicity has been explored in recent years. The review summarized all kinds of immunosuppressants and their relationship with ge-netic polymorphisms,including the SNPs of related enzymes about pharmacokinetics and pharmacodynamics,the SNPs of donor and tar-get site. The review focused on the current situation and progress in the related research areas.