中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
875-878
,共4页
迟雪梅%王阿琴%王新月%鄢丰%姚忠立%张洪记
遲雪梅%王阿琴%王新月%鄢豐%姚忠立%張洪記
지설매%왕아금%왕신월%언봉%요충립%장홍기
克拉霉素%溶出度%微孔滤膜%吸附率%干扰试验
剋拉黴素%溶齣度%微孔濾膜%吸附率%榦擾試驗
극랍매소%용출도%미공려막%흡부솔%간우시험
Clarithromycin%Dissolution%Microporous membrane%Adsorption rate%Interference test
目的：查找克拉霉素片溶出度偏低的原因，研究滤膜吸附对克拉霉素片不同时间点的溶出度结果的干扰程度，探索克拉霉素片溶出液合适的处理方法。方法：选择两种不同厂家的克拉霉素片剂，按照日本橘皮书溶出度方法制备溶出液，经不同方式处理后，检测其溶出度计算滤膜吸附率。结果：14种微孔滤膜对两个厂家的克拉霉素均有不同的吸附作用，且有的滤膜其吸附率超过了规定限度。结论：通过蒸煮滤膜和更换美国进口膜均能降低克拉霉素的吸附率；弃去初滤液的体积>5 ml或者离心处理溶出液均能有效减少和防止滤膜对药物吸附产生的干扰。
目的：查找剋拉黴素片溶齣度偏低的原因，研究濾膜吸附對剋拉黴素片不同時間點的溶齣度結果的榦擾程度，探索剋拉黴素片溶齣液閤適的處理方法。方法：選擇兩種不同廠傢的剋拉黴素片劑，按照日本橘皮書溶齣度方法製備溶齣液，經不同方式處理後，檢測其溶齣度計算濾膜吸附率。結果：14種微孔濾膜對兩箇廠傢的剋拉黴素均有不同的吸附作用，且有的濾膜其吸附率超過瞭規定限度。結論：通過蒸煮濾膜和更換美國進口膜均能降低剋拉黴素的吸附率；棄去初濾液的體積>5 ml或者離心處理溶齣液均能有效減少和防止濾膜對藥物吸附產生的榦擾。
목적：사조극랍매소편용출도편저적원인，연구려막흡부대극랍매소편불동시간점적용출도결과적간우정도，탐색극랍매소편용출액합괄적처리방법。방법：선택량충불동엄가적극랍매소편제，안조일본귤피서용출도방법제비용출액，경불동방식처리후，검측기용출도계산려막흡부솔。결과：14충미공려막대량개엄가적극랍매소균유불동적흡부작용，차유적려막기흡부솔초과료규정한도。결론：통과증자려막화경환미국진구막균능강저극랍매소적흡부솔；기거초려액적체적>5 ml혹자리심처리용출액균능유효감소화방지려막대약물흡부산생적간우。
Objective:To find the reasons for the low dissolution of clarithromycin tablets and study the interference from filter film adsorption at various time points to explore the appropriate processing approach for dissolution solution of clarithromycin tablets. Meth-ods:Clarithromycin tablets from two different manufacturers were used. The dissolution solution was prepared according to Japanese Orange Book. The dissolution was determined after different processing and the adsorption rate of the filter film was calculated. Re-sults:Totally 14 kinds of filter films were tested with different adsorption for clarithromycin, and the adsorption rate of some kinds of filter films exceeded the prescribed limit. Conclusion:The absorption rate of filter films for clarithromycin can be decreased by boiling the films and using American membranes. The interference from filter film adsorption can be reduced and inhibited by rejecting the first filtrate above 5ml or centrifuging dissolution solution.
