CAJ | 학술논문

目的：观察加贝酯（gabexate mesilate GM）在梗阻性黄疸术前保肝的疗效。方法低剂量治疗组加用加贝酯300mg，加入5％葡萄糖液250ml中静滴；高剂量治疗组加用加贝酯500mg，加入5％葡萄糖液250ml中静滴；对照组每日予极化液(普通胰岛素10U和l0％氯化钾l0ml加入5%葡萄糖液500ml中静脉滴注，2次/d；平均用药时间3~5d，且均在术前使用。结果治疗组丙氨酸氨基转移酶(ALT)，天冬氨酸氨基转移酶(AST)，前白蛋白(PA)治疗前与治疗后与对照组相比有明显好转，差异有统计学意义(P<0.05)；血清总胆红素(TBiL)降低，两治疗组无显著性差(P>0.05)。结论加贝酯对梗阻性黄疸术前保肝有很好的疗效。
목적：관찰가패지（gabexate mesilate GM）재경조성황달술전보간적료효。방법저제량치료조가용가패지300mg，가입5％포도당액250ml중정적；고제량치료조가용가패지500mg，가입5％포도당액250ml중정적；대조조매일여겁화액(보통이도소10U화l0％록화갑l0ml가입5%포도당액500ml중정맥적주，2차/d；평균용약시간3~5d，차균재술전사용。결과치료조병안산안기전이매(ALT)，천동안산안기전이매(AST)，전백단백(PA)치료전여치료후여대조조상비유명현호전，차이유통계학의의(P<0.05)；혈청총담홍소(TBiL)강저，량치료조무현저성차(P>0.05)。결론가패지대경조성황달술전보간유흔호적료효。
Objective to observe gabexate mesilate in obstructive jaundice before operation the curative ef ect of protecting liver. Method lower dose treatment group with 300mg GM injection was implement into 5% GS 250ml; High dose treatment group added with 500mg GM injection was implement into 5% GS 250ml; while only polarizedfluid was used in the control group.Al the treatment was used twice per day prior to surgery and lasted 3~5 days. Results The serum levels of ALT,AST as wel as PA in experimental group were shown superior to those in the control group (al P<0.05).The serum level of TBIL decreased in both treatment groups had no significant dif erence (P>0.05). Conclusions:double ester of obstructive jaundice preoperative liver have good curative ef ect.