CAJ | 학술논문

目的：探讨小儿哮喘的免疫功能状态。方法选取88例哮喘患儿进行CD4、CD8、CD4/CD8、IgE、EOS、eNO、红细胞CD35、红白细胞CD59的检测，并与健康同龄儿进行比较。结果CD4、CD8数值哮喘组均低于对照组（P均＜0.05），IgE、eNO数值哮喘组明显高于对照组（P均＜0.01），EOS数值哮喘组高于对照组（P均＜0.05）；红细胞CD35、CD59、白细胞CD59与对照组相比差异无统计学意义（P均＞0.05），红细胞自然免疫粘附肿瘤花环率（NTRR）较对照组（24.02±4.86）明显降低，差异有显著统计学意义（P＜0.01）。结论哮喘儿童存在免疫功能紊乱，在治疗上应进行免疫功能调整。
목적：탐토소인효천적면역공능상태。방법선취88례효천환인진행CD4、CD8、CD4/CD8、IgE、EOS、eNO、홍세포CD35、홍백세포CD59적검측，병여건강동령인진행비교。결과CD4、CD8수치효천조균저우대조조（P균＜0.05），IgE、eNO수치효천조명현고우대조조（P균＜0.01），EOS수치효천조고우대조조（P균＜0.05）；홍세포CD35、CD59、백세포CD59여대조조상비차이무통계학의의（P균＞0.05），홍세포자연면역점부종류화배솔（NTRR）교대조조（24.02±4.86）명현강저，차이유현저통계학의의（P＜0.01）。결론효천인동존재면역공능문란，재치료상응진행면역공능조정。
Objective To investigate the change of immunologic Cytokine in children with asthma. Methods CD4,CD8,CD4/CD8,IgE, EOS,eNO,CD35 and CD59 of Erythrocyte,CD59 of in 88 cases with asthma. The resμLts were compared with healthy children of the same age. Results CD4 and CD8 were lower in asthma group were lower than that in control group(P<0.05). IgE and eNO were obviously higher than that in control group(P<0.01). EOS were higher than that in control group(P<0.05). Compared with control group, the quantity of CD35 and CD59 had no obvious changes(P>0.05)and NTRR obviously fell in observation group(P<0.01). Conclusion There was immune functional defect in children with asthma. Adjusting the immune function shoμLd be emphasized in treatment to children with asthma.