中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2013年
33期
1-2,3
,共3页
马晋%张杰%张颖%余其贵
馬晉%張傑%張穎%餘其貴
마진%장걸%장영%여기귀
老年慢性阻塞性肺疾病急性加重%血管内皮生长因子%诊断%APACHE III评分%相关因素
老年慢性阻塞性肺疾病急性加重%血管內皮生長因子%診斷%APACHE III評分%相關因素
노년만성조새성폐질병급성가중%혈관내피생장인자%진단%APACHE III평분%상관인소
Acute exacerbations of chronic obstructive pulmonary disease%Vascular endothelial growth factor%Diagnosis%APACHE III scale%Correlation
目的：探讨老年AECOPD患者中血管内皮生长因子(VEGF)水平的诊断价值及其与急性生理学与慢性健康状况(APACHE III)评分之间的相关性。方法收集、观察60例老年AECOPD患者,30例COPD稳定期患者,30例健康老年人；入院后24 h内行、超敏C-反应蛋白(his-CRP)、降钙素原(PCT)、白细胞(WBC)、中性粒细胞百分比(N)等相关检查；并记录入院24 h内及治疗第8天APACHE III,治疗前后动态观察VEGF值及APACHE III评分变化。结果①与超敏C-反应蛋白、白细胞、降钙素原等相比, VEGF作为诊断AECOPD的单一指标是最好的。②治疗后VEGF值(109.16±50.85)、APACHE III值(26.45±3.37)明显低于治疗前(明显改善)VEGF值(213.91±72.00)、APACHE III(42.35±4.22)(P<0.05), VEGF水平与APACHE III评分明显相关。结论血清VEGF是诊断慢性阻塞性肺疾病急性加重的一个较好指标,判别效果高于PCT、His-CRP、WBC、N；VEGF值与APACHE III具有显著相关性,可作为老年AECOPD患者临床病情严重程度判断及预后的一个重要指标。
目的：探討老年AECOPD患者中血管內皮生長因子(VEGF)水平的診斷價值及其與急性生理學與慢性健康狀況(APACHE III)評分之間的相關性。方法收集、觀察60例老年AECOPD患者,30例COPD穩定期患者,30例健康老年人；入院後24 h內行、超敏C-反應蛋白(his-CRP)、降鈣素原(PCT)、白細胞(WBC)、中性粒細胞百分比(N)等相關檢查；併記錄入院24 h內及治療第8天APACHE III,治療前後動態觀察VEGF值及APACHE III評分變化。結果①與超敏C-反應蛋白、白細胞、降鈣素原等相比, VEGF作為診斷AECOPD的單一指標是最好的。②治療後VEGF值(109.16±50.85)、APACHE III值(26.45±3.37)明顯低于治療前(明顯改善)VEGF值(213.91±72.00)、APACHE III(42.35±4.22)(P<0.05), VEGF水平與APACHE III評分明顯相關。結論血清VEGF是診斷慢性阻塞性肺疾病急性加重的一箇較好指標,判彆效果高于PCT、His-CRP、WBC、N；VEGF值與APACHE III具有顯著相關性,可作為老年AECOPD患者臨床病情嚴重程度判斷及預後的一箇重要指標。
목적：탐토노년AECOPD환자중혈관내피생장인자(VEGF)수평적진단개치급기여급성생이학여만성건강상황(APACHE III)평분지간적상관성。방법수집、관찰60례노년AECOPD환자,30례COPD은정기환자,30례건강노년인；입원후24 h내행、초민C-반응단백(his-CRP)、강개소원(PCT)、백세포(WBC)、중성립세포백분비(N)등상관검사；병기록입원24 h내급치료제8천APACHE III,치료전후동태관찰VEGF치급APACHE III평분변화。결과①여초민C-반응단백、백세포、강개소원등상비, VEGF작위진단AECOPD적단일지표시최호적。②치료후VEGF치(109.16±50.85)、APACHE III치(26.45±3.37)명현저우치료전(명현개선)VEGF치(213.91±72.00)、APACHE III(42.35±4.22)(P<0.05), VEGF수평여APACHE III평분명현상관。결론혈청VEGF시진단만성조새성폐질병급성가중적일개교호지표,판별효과고우PCT、His-CRP、WBC、N；VEGF치여APACHE III구유현저상관성,가작위노년AECOPD환자림상병정엄중정도판단급예후적일개중요지표。
Objective To investigate the relationship between the vascular endothelial growth factor (VEGF) and the acute physiology and chronic health evaluation (APACHE) III in the old patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Methods To observed 60 old patients with AECOPD, 30 with COPD and 30 normal elders, test VEGF, serum procalcitionin, His-CRP, N and WBC within 24 hours, and record APACHE III within 24 hours and the 8th day after treatment;to compare dynamically the change of VEGF and APACHE III before and after the treatment for the old patients. Results It was significant correlation between the VEGF (109.16±50.85) and APACHE III (26.45±3.37) after treatment, which was lower than VEGF (213.91±72.00) and APACHEIII (42.35±4.22) (P<0.05) before the treatment. Conclusion The measurement of the VEGF level is helpful for diagnosing AECOPD in the elderly;it is significant correlation between the VEGF and APACHE III, which can be an important index for judging the degree and prognosis of the old patients with AECOPD.
