当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
33期
3-4
,共2页
宫颈上皮内瘤变(CIN)%液基薄层细胞检测(TCT)%高危型人乳头瘤病毒(HR-HPV)
宮頸上皮內瘤變(CIN)%液基薄層細胞檢測(TCT)%高危型人乳頭瘤病毒(HR-HPV)
궁경상피내류변(CIN)%액기박층세포검측(TCT)%고위형인유두류병독(HR-HPV)
Cervical intraepithelial neoplasias%Thinprep cytologic test%High-risk human papillomavirus
目的：探讨高危型HPV/TCT检测在宫颈CINⅠ随访中的应用。方法将2010年1月-2013年1月妇科门诊及住院收治的188例宫颈上皮内瘤变患者进行TCT检测，运用第二代杂交捕获实验的方式进行免疫学和化学发光技术让基因信号放大的微孔板对标本中的病毒进行HR-HPV的检测，颈管刷采集宫颈脱落细胞进行液基薄层细胞涂片，TBS分级系统进行细胞学检测。结果188例患者中炎症占78.19%，ASC-US及以上病变细胞学阳性率21.88%，CINⅠ病变阳性率17.55%，二者相比，差异没有统计学意义（χ2=0.05，P＞0.05）；HR-HPV阳性率17.02%，包括慢性炎症阳性率为7.43%（11/148），CINⅠ及以上阳性率为52.5%，二者相比差异有统计学意义（χ2=45.64，P＜0.05）。结论高危型HPV/TCT检测能够作为ASCUS患者的分流手段，降低漏诊率。
目的：探討高危型HPV/TCT檢測在宮頸CINⅠ隨訪中的應用。方法將2010年1月-2013年1月婦科門診及住院收治的188例宮頸上皮內瘤變患者進行TCT檢測，運用第二代雜交捕穫實驗的方式進行免疫學和化學髮光技術讓基因信號放大的微孔闆對標本中的病毒進行HR-HPV的檢測，頸管刷採集宮頸脫落細胞進行液基薄層細胞塗片，TBS分級繫統進行細胞學檢測。結果188例患者中炎癥佔78.19%，ASC-US及以上病變細胞學暘性率21.88%，CINⅠ病變暘性率17.55%，二者相比，差異沒有統計學意義（χ2=0.05，P＞0.05）；HR-HPV暘性率17.02%，包括慢性炎癥暘性率為7.43%（11/148），CINⅠ及以上暘性率為52.5%，二者相比差異有統計學意義（χ2=45.64，P＜0.05）。結論高危型HPV/TCT檢測能夠作為ASCUS患者的分流手段，降低漏診率。
목적：탐토고위형HPV/TCT검측재궁경CINⅠ수방중적응용。방법장2010년1월-2013년1월부과문진급주원수치적188례궁경상피내류변환자진행TCT검측，운용제이대잡교포획실험적방식진행면역학화화학발광기술양기인신호방대적미공판대표본중적병독진행HR-HPV적검측，경관쇄채집궁경탈락세포진행액기박층세포도편，TBS분급계통진행세포학검측。결과188례환자중염증점78.19%，ASC-US급이상병변세포학양성솔21.88%，CINⅠ병변양성솔17.55%，이자상비，차이몰유통계학의의（χ2=0.05，P＞0.05）；HR-HPV양성솔17.02%，포괄만성염증양성솔위7.43%（11/148），CINⅠ급이상양성솔위52.5%，이자상비차이유통계학의의（χ2=45.64，P＜0.05）。결론고위형HPV/TCT검측능구작위ASCUS환자적분류수단，강저루진솔。
Objective To research the application of high risk type HPV/TCT detection in the follow-up of cervical intraepithelial neoplasiasⅠ. Methods 188 outpatient and hospitalized patients of department of gynaecology with cervical intraepithelial neoplasia, from January 2010 to January 2010, were treated with TCT detection. Detecting high-risk human papillomavirus by using the second generation of hybrid capture experiment immunological and chemiluminescence technology for gene with the method of signal amplification of microporous surface specimens. Cervical exfoliated cells were collected with neck tube brush for liquid thin layer cell smear. TBS classification system was used for cytological examination. Results The inflammation rate in 188 patients was 78.19%, ASC-US and above lesions cytology positive rate was 21.88%,and CINⅠlesions positive rate was 17.55%. And the difference was no statistical significance (χ2=0.05, P>0.05).The high-risk human papillomavirus rate was 17.02%. And the positive rate chronic inflammation was 7.43% (11/148), CINⅠ and above positive rate was 52.5%. And the difference was statistical significance(χ2=45.64,P<0.05). Conclusion HR-HPV/TCT detection can be used as a shunt means, decrease the rate of missed diagnosis of ASCUS patients.
