中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
35期
6-7
,共2页
纳洛酮%慢性呼吸衰竭%肺性脑病
納洛酮%慢性呼吸衰竭%肺性腦病
납락동%만성호흡쇠갈%폐성뇌병
Naloxone%Chronic respiratory failure%Pulmonary encephalopathy
目的：对纳洛酮治疗慢性呼吸衰竭并肺性脑病的临床效果进行分析和观察。方法：以本院2009年1月-2012年1月收治的60例慢性呼吸衰竭并发肺性脑病患者为研究对象，采用随机分配的原则将所有患者分成对照组和试验组各30例。对照组患者采用常规的治疗措施，试验组患者则在常规治疗措施的基础上，增加纳洛酮进行治疗。对两组患者的血气分析、清醒时间以及临床效果进行观察和比较。结果：两组患者在血气分析上均有效改善。治疗后，两组患者的PaO2以及PaCO2均有明显变化，PaO2显著升高，PaCO2显著下降，两组治疗前后比较差异均有统计学意义（P<0.05）；试验组清醒时间明显短于对照组患者，两组比较差异有统计学意义（P<0.05）。试验组的总有效率明显高于对照组，两组比较差异有统计学意义（P<0.05）。结论：对慢性呼吸衰竭并发肺性脑病患者使用纳洛酮进行治疗，能够有效帮助患者恢复神志，有利于肺通气的改善，具有较高的临床应用价值，值得推广和普及。
目的：對納洛酮治療慢性呼吸衰竭併肺性腦病的臨床效果進行分析和觀察。方法：以本院2009年1月-2012年1月收治的60例慢性呼吸衰竭併髮肺性腦病患者為研究對象，採用隨機分配的原則將所有患者分成對照組和試驗組各30例。對照組患者採用常規的治療措施，試驗組患者則在常規治療措施的基礎上，增加納洛酮進行治療。對兩組患者的血氣分析、清醒時間以及臨床效果進行觀察和比較。結果：兩組患者在血氣分析上均有效改善。治療後，兩組患者的PaO2以及PaCO2均有明顯變化，PaO2顯著升高，PaCO2顯著下降，兩組治療前後比較差異均有統計學意義（P<0.05）；試驗組清醒時間明顯短于對照組患者，兩組比較差異有統計學意義（P<0.05）。試驗組的總有效率明顯高于對照組，兩組比較差異有統計學意義（P<0.05）。結論：對慢性呼吸衰竭併髮肺性腦病患者使用納洛酮進行治療，能夠有效幫助患者恢複神誌，有利于肺通氣的改善，具有較高的臨床應用價值，值得推廣和普及。
목적：대납락동치료만성호흡쇠갈병폐성뇌병적림상효과진행분석화관찰。방법：이본원2009년1월-2012년1월수치적60례만성호흡쇠갈병발폐성뇌병환자위연구대상，채용수궤분배적원칙장소유환자분성대조조화시험조각30례。대조조환자채용상규적치료조시，시험조환자칙재상규치료조시적기출상，증가납락동진행치료。대량조환자적혈기분석、청성시간이급림상효과진행관찰화비교。결과：량조환자재혈기분석상균유효개선。치료후，량조환자적PaO2이급PaCO2균유명현변화，PaO2현저승고，PaCO2현저하강，량조치료전후비교차이균유통계학의의（P<0.05）；시험조청성시간명현단우대조조환자，량조비교차이유통계학의의（P<0.05）。시험조적총유효솔명현고우대조조，량조비교차이유통계학의의（P<0.05）。결론：대만성호흡쇠갈병발폐성뇌병환자사용납락동진행치료，능구유효방조환자회복신지，유리우폐통기적개선，구유교고적림상응용개치，치득추엄화보급。
Objective:To analyze and observe the clinical effect of the naloxone in the treatment of chronic respiratory failure and pulmonary encephalopathy. Method:The clinical study mainly by the hospital from January 2009 to January 2012 were analyzed in 60 cases of chronic respiratory failure complicated by pulmonary encephalopathy patients as the research object,based on the principle of random distribution,patients were divided into the control group and the experimental group,each group of 30 cases. The control group was treated by routine treatment,the experimental group patients on the basis of routine treatment,increasing treated with naloxone. On two groups of patients with blood gas analysis,awaked time and clinical effect were observed and compared.Result:All patients of PaO2 and PaCO2 were changed significantly. PaO2 was significant increasing and PaCO2 was significant decreasing,and the difference of before and after treatment between the two groups were all statistically significant(P<0.05). The awaked time of the experimental group was significantly shorter than the control group(P<0.05)and clinical effect rate of the experimental group was significantly better than the control group(P<0.05).Conclusion:For patients with chronic respiratory failure complicated by pulmonary encephalopathy treated with naloxone, can effectively help patients recover consciousness,is beneficial to the improvement of pulmonary ventilation,is of high clinical application value,worthy of promotion and popularization.
