CAJ | 학술논문

目的：探讨替加环素（TGC ）治疗免疫力低下合并重症感染的血液病患者疗效及安全性。方法回顾分析10例次使用TGC治疗免疫力低下的血液病重症感染患者的临床资料。结果10例次血液病重症感染患者，1例接受TGC单药治疗有效，9例接受TGC联合抗菌药物治疗中，7例有效。TGC平均使用（7．70±2．31）d，起效时间平均为（2．37±0．92）d。不良反应可以耐受。结论使用TGC能有效控制免疫力低下恶性血液病患者的重症感染，安全耐受。TGC联合用药方式可以考虑作为免疫力低下的血液病患者严重感染时拯救性治疗选择。
목적：탐토체가배소（TGC ）치료면역력저하합병중증감염적혈액병환자료효급안전성。방법회고분석10례차사용TGC치료면역력저하적혈액병중증감염환자적림상자료。결과10례차혈액병중증감염환자，1례접수TGC단약치료유효，9례접수TGC연합항균약물치료중，7례유효。TGC평균사용（7．70±2．31）d，기효시간평균위（2．37±0．92）d。불량반응가이내수。결론사용TGC능유효공제면역력저하악성혈액병환자적중증감염，안전내수。TGC연합용약방식가이고필작위면역력저하적혈액병환자엄중감염시증구성치료선택。
Objective To analyse the efficacy of tigecycline (TGC)on severe infections of hypoimmunitic patients with hematologi-cal disease.Methods Data from 10 hypoimmunitic patients with hematological disease receiving TGC on severe infections were collected and analysed retrospectively.Results From 9 patients received TGC in combination with other antibiotic agents,7 patients achieved favorable re-sponse.Treatment was successful in 1 patient treated by TGC mono-therapy.The mean duration of TGC therapy was 7.70 ±2.31 days and the mean effect time after TGC was 2.37 ±0.92 days.The toxicity of TGC was mild and tolerated.Conclusion TGC is an effective and well tol-erated empirical treatment of severe infections in hypoimmunitic patients with hematological disease.TGC in combination may be a successful alternative for salvage treatment of severe infections in those patients.