CAJ | 학술논문

目的：探讨自体外周血造血干细胞移植（ ASCT ）支持下大剂量化疗在外周T细胞淋巴瘤一线治疗中的疗效。方法总结2000年1月至2011年1月间进行的自体外周造血干细胞移植支持下的大剂量化疗的23例外周T细胞淋巴瘤患者的临床资料，并与同期进行的23例常规治疗的患者作非随机比较，所有患者均予以E-CHOP方案化疗6～8周期，移植组达完全缓解或部分缓解后行ASCT支持下大剂量化疗。结果移植组近期疗效与常规化疗组比较差异无统计学意义（ P ＞0.05），移植组5年总生存率（OS）（58％）高于常规化疗组（32％），移植组5年无病生存率（DFS）（45％）亦高于常规化疗组（21％），差异皆有统计学意义（ P ＜0.05）。两组严重毒副反应比较中，仅移植组Ⅳ度骨髓抑制发生率（100％）高于常规化疗组（13％），差异有统计学意义（ P ＜0.01）。结论 ASCT支持下大剂量化疗治疗外周T细胞淋巴瘤安全有效，其疗效优于常规化疗，可作为PTCL一线治疗。
목적：탐토자체외주혈조혈간세포이식（ ASCT ）지지하대제양화료재외주T세포림파류일선치료중적료효。방법총결2000년1월지2011년1월간진행적자체외주조혈간세포이식지지하적대제양화료적23예외주T세포림파류환자적림상자료，병여동기진행적23례상규치료적환자작비수궤비교，소유환자균여이E-CHOP방안화료6～8주기，이식조체완전완해혹부분완해후행ASCT지지하대제양화료。결과이식조근기료효여상규화료조비교차이무통계학의의（ P ＞0.05），이식조5년총생존솔（OS）（58％）고우상규화료조（32％），이식조5년무병생존솔（DFS）（45％）역고우상규화료조（21％），차이개유통계학의의（ P ＜0.05）。량조엄중독부반응비교중，부이식조Ⅳ도골수억제발생솔（100％）고우상규화료조（13％），차이유통계학의의（ P ＜0.01）。결론 ASCT지지하대제양화료치료외주T세포림파류안전유효，기료효우우상규화료，가작위PTCL일선치료。
Objective To investigate the outcomes of unselected peripheral T cell lymphoma (PTCL) patients treated with in-tensive first-line chemotherapy with high-dose therapy followed by autologous stem cell transplantation (ASCT).Methods Here a nonrandom study was reported for 23 PTCL patients treated with first-line intensive chemotherapy followed by autologous stem cell trans-plantation and 23 PTCL patients treated with conventional chemotherapy during January in 2000 to 2011 .All patients had received E-CHOP for 6~8 cycles, and autologous stem cell transplantation group was administrated with intensive chemotherapy followed by ASCT after complete remission or partial remission .Results There was no statistically significant difference in short-term therapeutic effect between two groups( P >0.05), but the 5-year overall survival(OS) of autologous stem cell transplantation group( 58%) was higher than conventional chemotherapy group , as well as 5-year disease-free survival time (DFS) (45%in autologous stem cell transplanta-tion group, and 21%in conventional chemotherapy group ) with both statistical significance ( P <0.05).Only the incidence of Ⅳ° myelosuppression in autologous stem cell transplantation group ( 100%) was higher than that in conventional chemotherapy group ( 13%) ( P <0.01 ) .Conclusions First-line intensive chemotherapy followed by autologous stem cell transplantation for peripheral T cell lymphoma was quietly safe utility , it was better than conventional chemotherapy which would be considered as first -line method.