CAJ | 학술논문

目的：观察缓释抗结核微球填充于骨支架后的骨密度测试情况，为减少术后抗结核治疗的副作用提供实验依据。方法采用骨密度仪分别观察人工同种异体骨（ A组）、利福平（ RFP ）缓释微球-人工同种异体骨缓释复合体（ B组）和RFP-人工同种异体骨复合体（ C组）灌注前后骨密度的变化。结果灌注前A、B、C三组骨密度差异无统计学意义[ A组：（0．191±0．018）g／cm2；B组：（0．186±0．016）g／cm2；C组：（0．189±0．018）g／cm2；P ＞0．05]，而灌注后A、B、C三组骨密度差异亦无统计学意义[A组：（0．191±0．018）g／cm2；B组：（0．179±0．023）g／cm2；C组：（0．185±0．021）g／cm2；P ＞0．05]。结论RFP微球使用超声波振荡方法可以与多孔隙的骨制备成抗结核缓释复合体，且灌注后不会对骨密度产生明显的干扰作用。
목적：관찰완석항결핵미구전충우골지가후적골밀도측시정황，위감소술후항결핵치료적부작용제공실험의거。방법채용골밀도의분별관찰인공동충이체골（ A조）、리복평（ RFP ）완석미구-인공동충이체골완석복합체（ B조）화RFP-인공동충이체골복합체（ C조）관주전후골밀도적변화。결과관주전A、B、C삼조골밀도차이무통계학의의[ A조：（0．191±0．018）g／cm2；B조：（0．186±0．016）g／cm2；C조：（0．189±0．018）g／cm2；P ＞0．05]，이관주후A、B、C삼조골밀도차이역무통계학의의[A조：（0．191±0．018）g／cm2；B조：（0．179±0．023）g／cm2；C조：（0．185±0．021）g／cm2；P ＞0．05]。결론RFP미구사용초성파진탕방법가이여다공극적골제비성항결핵완석복합체，차관주후불회대골밀도산생명현적간우작용。
Objective To investigate bone mineral density ( BMD ) after filling in the bone scaffolds with anti-tuberculosis controlled-release microspheres, and provide experimental basis for decrease of the side effects of anti-tuberculosis therapy after spinal surgery.Methods The bone densitometer was used to observe the changes of bone mineral density before and after the infusion with the artificial allograft bone (Group A), the controlled release complex of the RFP controlled-release microspheres-artificial allograft bone (Group B), and RFP-artificial allograft bone complex (Group C), respectively.Results BMDs of three groups before perfusion were not different significantly [Group A:(0.191 ±0.018)g/cm2;Group B:(0.186 ±0.016)g/cm2;Group C:(0.189 ±0.018)g/cm2;P >0.05].BMDs of three groups after perfusion were not different significantly [Group A:(0.191 ±0.018)g/cm2;Group B:(0.179 ±0.023)g/cm2;Group C:(0.185 ±0.021)g/cm2;P >0.05].Conclusions RFP microspheres using ultrasonic vibration method and the porous bone were prepared to controlled-release anti-tuberculosis complex .BMD of three groups after perfusion were not influenced obviously .