CAJ | 학술논문

目的：使用暴露边界比法计算我国居民的乙酰甲胺磷膳食暴露量，并进行风险评估。方法通过大鼠灌胃染毒21 d，得到乙酰甲胺磷的基准剂量值。整合2002年全国营养与健康状况调查中膳食调查数据和2000-2006年全国食品污染物监测网、2005-2006年海关出口农产品乙酰甲胺磷监测数据，使用概率评估方法计算全国居民乙酰甲胺磷膳食暴露量，通过计算得出暴露边界比，并进行暴露风险的评估。结果动物实验得到乙酰甲胺磷的基准剂量值为0．75 mg·kg -1，基准剂量95％下限值为0．51 mg·kg -1；未成年人的农药暴露水平高于成年人，通过暴露边界比法得到1～6岁、7～17岁和18岁以上人群存在暴露风险的比例分别在5％，1％和0．1％左右。结论在全国范围内，有一部分居民存在膳食暴露风险，同时未成年人的高暴露水平应当引起关注。
목적：사용폭로변계비법계산아국거민적을선갑알린선식폭로량，병진행풍험평고。방법통과대서관위염독21 d，득도을선갑알린적기준제량치。정합2002년전국영양여건강상황조사중선식조사수거화2000-2006년전국식품오염물감측망、2005-2006년해관출구농산품을선갑알린감측수거，사용개솔평고방법계산전국거민을선갑알린선식폭로량，통과계산득출폭로변계비，병진행폭로풍험적평고。결과동물실험득도을선갑알린적기준제량치위0．75 mg·kg -1，기준제량95％하한치위0．51 mg·kg -1；미성년인적농약폭로수평고우성년인，통과폭로변계비법득도1～6세、7～17세화18세이상인군존재폭로풍험적비례분별재5％，1％화0．1％좌우。결론재전국범위내，유일부분거민존재선식폭로풍험，동시미성년인적고폭로수평응당인기관주。
OBJECTIVE Calculate the dietary exposure and exposure risk of Chinese consumers to acephate,using the margin of exposure method.METHODS Determine the bench mark dose of acephate by 21 -day gavage experiment of rats.According to the data from the 2002 National Diet and Nutrition Survey,the 2000 -2006 national food conta mination monitoring program,the 2005 -2006 export monitoring data of customs,calculate the dietary exposure of Chinese consumers to acephate by probabilistic assessment.Estimate the exposure risk by co mparing the margin of exposure with 100. RESULTS The bench mark dose of acephate was 0.75 mg·kg -1 ,the BMDL was 0.51 mg·kg -1 .The exposure of children was higher than that of adults.The proportion at risk of group 1 -6 y,7 -17 y and 18 y or higher was 5%,1 % and 0.1 %,respectively.CONCLUSION So me consumers was of dietary exposure risk to acephate.The high exposure of children should be of great concern.