CAJ | 학술논문

目的：研究福赛坦氏菌和动脉粥样硬化的相关性。方法收集需要进行动脉外科手术的患者从中选取伴有慢性牙周炎的病例，采集龈下菌斑和动脉粥样硬化斑块病理标本，以PCR法检测动脉粥样硬化斑块和龈下菌斑中福赛坦氏菌（Tf），并对其扩增产物进行测序和比对。结果动脉粥样硬化斑块中 Tf 的检出率为29％，动脉粥样硬化斑块和龈下菌斑中同时检出的比率为24％，基因比对显示两者具有高度同源性。结论 Tf可能在动脉粥样硬化发生发展中可能起着相应的作用。
목적：연구복새탄씨균화동맥죽양경화적상관성。방법수집수요진행동맥외과수술적환자종중선취반유만성아주염적병례，채집간하균반화동맥죽양경화반괴병리표본，이PCR법검측동맥죽양경화반괴화간하균반중복새탄씨균（Tf），병대기확증산물진행측서화비대。결과동맥죽양경화반괴중 Tf 적검출솔위29％，동맥죽양경화반괴화간하균반중동시검출적비솔위24％，기인비대현시량자구유고도동원성。결론 Tf가능재동맥죽양경화발생발전중가능기착상응적작용。
Objective To study the correlation between Tannerella Forsythensis (Tf)and athero-sclerosis . Methods Patients scheduled for arterial reconstruction surgery and also with chronic periodon-titis were enrolled in this study . The atheromatous plaques were collected during the surgery and subgin-gival plaques were collected before the operation ,and those collected plaques were examined using PCR to detect Tf ,then PCR products were sequenced and compared . Results In 21 cases ,the detection rate of Tf in the atherosclerotic plaques was 29% ,and the detection rate of two sources Tf in the same patient was 24% . While using blast contrast to compare the PCR products examined in the two places ,we found significantly correlation in nucleotide similarity . Conclusion Tf may play roles in the occurrence and de-velopment of atheromatous plaques .