CAJ | 학술논문

目的：探讨饮酒、吸烟与口腔癌的关系。方法采用病例对照研究收集相关资料，病例为福建医科大学附属第一医院口腔科经病理确诊的新发口腔癌病例206例，对照为体检人群及其他科室患者584例。每位研究对象进行面对面的问卷调查。采用非条件Logistic回归对资料进行分析，估算饮酒、吸烟与口腔癌发病风险的调整比值比（OR）及95％可信区间（95％ CI），并分析饮酒与吸烟的交互作用。结果饮酒、吸烟可显著增加口腔癌的发病风险，调整 OR值为2．06（95％ CI：1．33～3．20），2．46（1．77～3．41）；开始饮酒年龄越早、平均每天饮酒精量的增加和饮酒年限的延长，饮酒者患口腔癌的危险性增大。其中平均每天饮酒精量超过60 g者与口腔癌有显著关联（P＜0．05），调整 OR值为5．98（95％ CI：3．26～10．95）；吸烟且饮酒者患口腔癌的危险性是不吸烟且不饮酒者的4．77倍（95％ C I：2．71～8．39），烟酒乘积项的调整 OR值为3．58（95％ C I：2．45～5．24），调整后相对超危险度比（RERI）为2．87（95％ CI：0．73～5．02）、归因比（AP）为0．60（95％ CI：0．33～0．87）、交互作用指数（S）为4．20（95％C I：0．95～18．66）。结论饮酒、吸烟是口腔癌的危险因素，饮酒与吸烟二者有协同作用，可增加口腔癌的发病风险。
목적：탐토음주、흡연여구강암적관계。방법채용병례대조연구수집상관자료，병례위복건의과대학부속제일의원구강과경병리학진적신발구강암병례206례，대조위체검인군급기타과실환자584례。매위연구대상진행면대면적문권조사。채용비조건Logistic회귀대자료진행분석，고산음주、흡연여구강암발병풍험적조정비치비（OR）급95％가신구간（95％ CI），병분석음주여흡연적교호작용。결과음주、흡연가현저증가구강암적발병풍험，조정 OR치위2．06（95％ CI：1．33～3．20），2．46（1．77～3．41）；개시음주년령월조、평균매천음주정량적증가화음주년한적연장，음주자환구강암적위험성증대。기중평균매천음주정량초과60 g자여구강암유현저관련（P＜0．05），조정 OR치위5．98（95％ CI：3．26～10．95）；흡연차음주자환구강암적위험성시불흡연차불음주자적4．77배（95％ C I：2．71～8．39），연주승적항적조정 OR치위3．58（95％ C I：2．45～5．24），조정후상대초위험도비（RERI）위2．87（95％ CI：0．73～5．02）、귀인비（AP）위0．60（95％ CI：0．33～0．87）、교호작용지수（S）위4．20（95％C I：0．95～18．66）。결론음주、흡연시구강암적위험인소，음주여흡연이자유협동작용，가증가구강암적발병풍험。
Objective To investigate the association between alcohol drinking ,tobacoo smoking and oral cancer . Methods We conducted a case-control study with 206 cases and 584 population-based controls . Patients were recruited from the First Clinical Medical College with pathologic confirmation . Control subjects were enrolled from hospital visitors and community population . Eligible participants were personally interviewed using a questionnaire . Unconditional logistic regression model and single fac-tor analysis was performed to calculate to alcohol drinking and oral cancer risk odds ratios (ORs) and 95%confidence intervals (CIs) ,and to analysis the interaction of alcohol drinking and smoking . Results Al-cohol drinking can significantly increase the risk of oral cancer ,ORs and CIs were 2 .06(95% CI:1 .33~3 .01) . As the earlier start drinking age ,the increasion of average alcohol consumption one day ,the ex-tension of drinking years ,drinkers increase risk of oral cancer . Among them ,drinkers who one day on average alcohol consumption more than 60 g has significant correlation on oral cancer (P< 0 .05) ,ORs were 5 .98 (95% CI:3 .26~10 .95);The risk of oral cancer with both smoking and drinking were 4 .77 times more than one neither smoking nor drinking (95% CI:2 .71~8 .39) . Using Logistic regression model ,the ORs were 3 .58(95% CI:2 .45~5 .24)of cross-product term of smoking and drinking . Adjus-ted RERI ,AP and S were 2 .87(95% CI:0 .73~5 .02) ,0 .60(95% CI:0 .33~0 .87) ,4 .20(95% CI:0 .95~18 .66) . Alcohol drinking have multiplication and addition interaction with smoking ,they could in-crease the risk of oral cancer . Conclusions There is synergistic effect between drinking and smoking , they could increase the risk of oral cancer .