CAJ | 학술논문

辅酶 Q（CoQ）是生物机体内广泛存在的脂溶性醌类化合物，在体内细胞线粒体呼吸链质子转移和电子传递中起重要作用，是细胞呼吸和能量代谢过程中一种必不可少的物质。CoQ 不但可能参与细胞线粒体呼吸链中的电子传递，维持细胞呼吸和能量代谢功能，而且可作为抗氧化剂参与机体的氧化还原反应。CoQ 通过维持线粒体 DNA 和基因的稳定促进细胞的生存，通过调节细胞线粒体通透性转换孔等起到独立的抗凋亡作用。人类周围环境中存在各种各样的化学毒物，通过饮水、摄食或呼吸等进入人体内，可对细胞线粒体造成不同程度的影响，因此，研究 CoQ 在外源化学物引起的细胞线粒体损伤中的作用对探讨干预或减轻外源化学物质对生物机体的损害作用具有重要的预防医学意义。本文从 CoQ 在细胞呼吸与能量代谢、氧化还原反应、线粒体 DNA 和基因表达及细胞凋亡中影响等方面对 CoQ 在线粒体损伤中的作用进行综述。
보매 Q（CoQ）시생물궤체내엄범존재적지용성곤류화합물，재체내세포선립체호흡련질자전이화전자전체중기중요작용，시세포호흡화능량대사과정중일충필불가소적물질。CoQ 불단가능삼여세포선립체호흡련중적전자전체，유지세포호흡화능량대사공능，이차가작위항양화제삼여궤체적양화환원반응。CoQ 통과유지선립체 DNA 화기인적은정촉진세포적생존，통과조절세포선립체통투성전환공등기도독립적항조망작용。인류주위배경중존재각충각양적화학독물，통과음수、섭식혹호흡등진입인체내，가대세포선립체조성불동정도적영향，인차，연구 CoQ 재외원화학물인기적세포선립체손상중적작용대탐토간예혹감경외원화학물질대생물궤체적손해작용구유중요적예방의학의의。본문종 CoQ 재세포호흡여능량대사、양화환원반응、선립체 DNA 화기인표체급세포조망중영향등방면대 CoQ 재선립체손상중적작용진행종술。
Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.