CAJ | 학술논문

目的观察雾化吸人高渗盐水在婴幼儿毛细支气管炎治疗中的临床疗效,探讨其在临床中的应用价值.方法选择本院儿科病房2010年10月至2012年10月收住的毛细支气管炎患儿共89例,随机分为两组,两组在一般常规治疗的基础上,治疗组加以高渗盐水(3％氯化钠)2ml±沙丁胺醇2.5 mg雾化吸入；对照组加以生理盐水(0.9％氯化钠)2 ml+沙丁胺醇2.5 mg雾化吸人；均使用氧气驱动的空气压缩雾化泵雾化吸入治疗,雾化吸人频率为Q8 h,雾化治疗时间持续到治愈出院.比较两组治疗后喘息缓解时间、咳嗽缓解时间、肺部哕音消失时间以及治疗前后临床病情严重程度评分改变.结果治疗组的喘息缓解时间、咳嗽缓解时间、肺部哕音消失时间、住院时间分别为(3.31±1.13)天、(4.61±0.72)天、(3.84±1.22)天、(5.75±1.40)天,均明显短于对照组的(4.50±0.94)天、(5.93±1.11)天、(5.15±1.31)天、(6.81±1.64)天,两组比较差异均具有统计学意义(P＜0.01).治疗组在治疗后第1、2、3、4天临床病情严重程度评分分别为(5.88±0.78)分、(5.01±0.59)分、(4.13±0.68)分、(3.59±0.70)分,均明显低于对照组的(6.95±0.82)分,(6.36±0.84)分、(5.57±0.64)分、(4.45±0.83)分,两组比较差异均具有统计学意义(P＜0.01).两组均未发生与雾化相关的严重不良反应(如急性支气管痉挛、血氧饱和度下降等).结论雾化吸入高渗盐水对于治疗婴幼儿毛细支气管炎的疗效显著优于生理盐水,其不仅可明显缩短喘息缓解时间、咳嗽缓解时间以及肺部哕音消失时间,并且能降低患儿临床病情严重程度评分,还可以明显缩短住院时间,且无明显不良反应,是一种安全有效的治疗手段.
목적 관찰무화흡인고삼염수재영유인모세지기관염치료중적림상료효,탐토기재림상중적응용개치.방법 선택본원인과병방2010년10월지2012년10월수주적모세지기관염환인공89례,수궤분위량조,량조재일반상규치료적기출상,치료조가이고삼염수(3％록화납)2ml±사정알순2.5 mg무화흡입；대조조가이생리염수(0.9％록화납)2 ml+사정알순2.5 mg무화흡인；균사용양기구동적공기압축무화빙무화흡입치료,무화흡인빈솔위Q8 h,무화치료시간지속도치유출원.비교량조치료후천식완해시간、해수완해시간、폐부홰음소실시간이급치료전후림상병정엄중정도평분개변.결과 치료조적천식완해시간、해수완해시간、폐부홰음소실시간、주원시간분별위(3.31±1.13)천、(4.61±0.72)천、(3.84±1.22)천、(5.75±1.40)천,균명현단우대조조적(4.50±0.94)천、(5.93±1.11)천、(5.15±1.31)천、(6.81±1.64)천,량조비교차이균구유통계학의의(P＜0.01).치료조재치료후제1、2、3、4천림상병정엄중정도평분분별위(5.88±0.78)분、(5.01±0.59)분、(4.13±0.68)분、(3.59±0.70)분,균명현저우대조조적(6.95±0.82)분,(6.36±0.84)분、(5.57±0.64)분、(4.45±0.83)분,량조비교차이균구유통계학의의(P＜0.01).량조균미발생여무화상관적엄중불량반응(여급성지기관경련、혈양포화도하강등).결론 무화흡입고삼염수대우치료영유인모세지기관염적료효현저우우생리염수,기불부가명현축단천식완해시간、해수완해시간이급폐부홰음소실시간,병차능강저환인림상병정엄중정도평분,환가이명현축단주원시간,차무명현불량반응,시일충안전유효적치료수단.
Objective To explore the clinical value and observe the clinical efficacy of hypertonic saline for capillary bronchitis in infants by aerosol inhalation.Methods 89 infants with capillary bronchitis hospitalized into the pediatric ward of our hospital from Oct.2010 to Oct.2012 were selected and randomly divided into two groups.On the basis of general conventional treatment,the treatment group was given aerosol inhalation of 2 ml hypertonic saline(3％ NaC1) and 2.5 mg salbutamol,and the control group was dealt with aerosol inhalation of 2 ml saline(0.9％ NaC1) and 2.5 mg salbutamol.Aerosol inhalation was used in both groups by air compression atomizing oxygen driven pumps Q8h until hospital discharge.Compared the remission time of gasp and cough,the time of pulmonary rales disappeared and the score changes of the clinical illness severity before and after treatment.Results The remission time of gasp and cough,the time of pulmonary rales disappeared and the time of hospitalization in treatment group were (3.31 ± 1.13) days,(4.61 ± 0.72) days,(3.84 ± 1.22) days,and (5.75 ± 1.40)days,respectively,which were significantly shorter than those of the control group ([4.50 ± 0.94],[5.93 ± 1.11],[5.15 ± 1.31],[6.81 ± 1.64] days),with significant differences between the two groups (P＜0.01).The scores of the clinical illness severity in treatment group after 1st,2nd,3rd,and 4th day's treatment were(5.88 ± 0.78)points,(5.01 ± 0.59)points,(4.13 ± 0.68) points,and(3.59 ± 0.70)points,respectively,which were lower than those of the control group([6.95-± 0.82],[6.36 ± 0.84],[5.57 ± 0.64],[4.45 ± 0.83] points),with significant differences between the two groups (P＜0.01).No serious atomization-relative adverse reactions (acute bronchospasm,decrease in blood oxygen saturation,etc) occurred in both groups.Conclusions The efficacy of aerosol inhalation of hypertonic saline for the capillary bronchitis infants is significantly better than that of saline.What' s more,aerosol inhalation of hypertonic saline is an effective and safe treatment,which can decrease the scores of the clinical illness severity in infants,obviously shorten the time of hospitalization and have no obvious adverse reactions.