CAJ | 학술논문

采用CCl4小鼠肝纤维化模型，给予不同剂量泥鳅冻干粉，检测小鼠血清中ALT、AST活性及肝组织中羟脯氨酸（Hyp）含量，并观察肝组织病理变化，探讨泥鳅冻干粉抗CCl4小鼠肝纤维化作用。结果表明，与模型组相比，泥鳅粉冻干粉明显降低CCl4诱导的肝纤维化小鼠血清ALT、AST活性，显著降低肝组织Hyp含量（P＜0.05）。病理学观察结果，泥鳅粉冻干粉给药组小鼠胶原纤维沉积明显减轻，假小叶结构明显减少。泥鳅冻干粉能预防小鼠肝纤维化的形成，具有抗肝纤维化作用。
채용CCl4소서간섬유화모형，급여불동제량니추동간분，검측소서혈청중ALT、AST활성급간조직중간포안산（Hyp）함량，병관찰간조직병리변화，탐토니추동간분항CCl4소서간섬유화작용。결과표명，여모형조상비，니추분동간분명현강저CCl4유도적간섬유화소서혈청ALT、AST활성，현저강저간조직Hyp함량（P＜0.05）。병이학관찰결과，니추분동간분급약조소서효원섬유침적명현감경，가소협결구명현감소。니추동간분능예방소서간섬유화적형성，구유항간섬유화작용。
To study the effect of Misgurnus anguillicaudatus lyophilized power on liver fibrosis, the model in mice was established by using CCl4. Given different doses of Misgurnus anguillicaudatus lyophilized power, the serum ALT and AST activities and tissue Hyp content were detected. The pathological changes of liver were observed. Results showed that the AST and ALT activities and Hyp levels were significantly decreased (P<0.05) in three doses groups of Misgurnus Anguillicaudatus lyophilized power, compared with the model group. The pathological improvements were observed. The fibrogenesis in liver tissues were markedly reduced and the formation of liver pseudoluboli was alleviated. The Misgurnus anguillicaudatus lyophilized power can prevent the formation of liver fibrosis induced by CCl4 in mice.