CAJ | 학술논문

目的探讨超敏C反应蛋白( hs-CRP)与维吾尔族老年单纯收缩期高血压( ISH)患者血管内皮功能之间的关系。方法选取维吾尔族老年ISH患者100例作为ISH组,维吾尔族老年原发性高血压( EH)患者100例作为EH组,并选择年龄与之相匹配的维吾尔族血压正常人群( NT )80例作为NT组。采用免疫透射比浊法测定血清 hs-CRP 水平、ELISA法测定血清内皮素1( ET-1)浓度, Griess法测定血清一氧化氮( NO)含量；运用超声技术测定血流介导的内皮依赖性血管舒张功能( FMD),动脉硬化检测仪测定颈-股动脉脉搏波传导速度( cfPWV)。采用直线相关分析及多元线性逐步回归分析法分析hs-CRP与ET-1、cfPWV、NO、FMD的相关性。结果与NT组比较,ISH组、EH组hs-CRP、cfPWV、ET-1明显升高( P <0.01),而 NO、FMD 明显降低( P <0.01)；ISH组hs-CRP、cfPWV、ET-1高于EH组(P<0.01)；ISH、EH两组间的NO、FMD差异无统计学意义。相关性分析表明, hs-CRP 与 ET-1、cfPWV 呈正相关( P <0.01),与NO、FMD呈负相关( P<0.01)。多元线性逐步回归分析显示hs-CRP、NO、ET-1、cfPWV是影响 FMD的主要因素( P<0.05)。结论维吾尔族老年ISH患者血清hs-CRP水平明显升高,且与FMD呈负相关。
목적탐토초민C반응단백( hs-CRP)여유오이족노년단순수축기고혈압( ISH)환자혈관내피공능지간적관계。방법선취유오이족노년ISH환자100례작위ISH조,유오이족노년원발성고혈압( EH)환자100례작위EH조,병선택년령여지상필배적유오이족혈압정상인군( NT )80례작위NT조。채용면역투사비탁법측정혈청 hs-CRP 수평、ELISA법측정혈청내피소1( ET-1)농도, Griess법측정혈청일양화담( NO)함량；운용초성기술측정혈류개도적내피의뢰성혈관서장공능( FMD),동맥경화검측의측정경-고동맥맥박파전도속도( cfPWV)。채용직선상관분석급다원선성축보회귀분석법분석hs-CRP여ET-1、cfPWV、NO、FMD적상관성。결과여NT조비교,ISH조、EH조hs-CRP、cfPWV、ET-1명현승고( P <0.01),이 NO、FMD 명현강저( P <0.01)；ISH조hs-CRP、cfPWV、ET-1고우EH조(P<0.01)；ISH、EH량조간적NO、FMD차이무통계학의의。상관성분석표명, hs-CRP 여 ET-1、cfPWV 정정상관( P <0.01),여NO、FMD정부상관( P<0.01)。다원선성축보회귀분석현시hs-CRP、NO、ET-1、cfPWV시영향 FMD적주요인소( P<0.05)。결론유오이족노년ISH환자혈청hs-CRP수평명현승고,차여FMD정부상관。
Objective To investigate the relationship between high-sensitivity C-reactive protein ( hs-CRP ) and vascular endothelial function of Uygur elderly patients with isolated systolic hypertension ( ISH ) . Methods 100 Uygur old patients with isolated systolic hypertension ( ISH) were enrolled as ISH group, recrutied pairs of essential hypertension ( EH) 100 cases as the EH group,another 80 age-matched normotension( NT) people were chosen as NT group. Serum high-sensitivity C-reactive protein (hs-CRP) and endothelin-1 (ET-1) concentration were meas-ured by turbidimetric immunoassay and ELISA method respectively. Nitric oxide ( NO) was determined by Griess method, the flow-mediated endothelium-dependent vasodilation function ( FMD) was detected through ultrasound technology,and carotid-femoral pulse wave conduction velocity ( cfPWV) was measured by automatic arteriosclero-sis detector. The association between hs-CRP and ET-1,cf-PWV,NO,FMD was described by linear correlation a-nalysis and multiple linear stepwise regression analysis. Results Compared with those of NT group,hs-CRP,cfP-WV,ET-1 in ISH and EH groups were higher (P<0.01),while the NO,FMD were lower(P<0.01);hs-CRP,cf-PWV,ET-1 in ISH groups were higher than EH group (P<0.01); the difference of NO,FMD between ISH and EH groups was not significant statistically. hs-CRP was positively correlated with ET-1 and cfPWV ( P<0.01 ) , but was negatively correlated with NO and FMD ( P<0.01 ) . Multiple linear stepwise regression analysis showed that hs-CRP,NO,ET-1,cfPWV were the main influencing factors of FMD(P<0.05). Conclusion hs-CRP level is significantly elevated in Uygur elderly patients with isolated systolic hypertension and negatively correlated with FMD.