CAJ | 학술논문

目的：探讨重组人干扰素a-2b不同用法治疗慢性乙型肝炎的临床效果。方法：选择我院70例慢性乙型肝炎患者，随机分为观察组和对照组。观察组给予重组人干扰素a-2b，疗程为12个月。对照组给予重组人干扰素a-2b，疗程为6个月。观察两组ALT复常率、HBeAg转阴率及HBeAg/抗HBe血清转换率改变情况。结果：观察组随访12个月的ALT复常率高于对照组，差异有统计学意义（P<0.05）。观察组治疗结束时、随访6个月、随访12个月的HBeAg转阴率、HBeAg/抗HBe血清转换率分别与对照组比较，差异有统计学意义（P<0.05）。结论：重组人干扰素a-2b长疗程治疗慢性乙型肝炎临床效果显著，值得借鉴。
목적：탐토중조인간우소a-2b불동용법치료만성을형간염적림상효과。방법：선택아원70례만성을형간염환자，수궤분위관찰조화대조조。관찰조급여중조인간우소a-2b，료정위12개월。대조조급여중조인간우소a-2b，료정위6개월。관찰량조ALT복상솔、HBeAg전음솔급HBeAg/항HBe혈청전환솔개변정황。결과：관찰조수방12개월적ALT복상솔고우대조조，차이유통계학의의（P<0.05）。관찰조치료결속시、수방6개월、수방12개월적HBeAg전음솔、HBeAg/항HBe혈청전환솔분별여대조조비교，차이유통계학의의（P<0.05）。결론：중조인간우소a-2b장료정치료만성을형간염림상효과현저，치득차감。
Objective :To explore the clinical effect of different usage of recombinant human interferon a-2b on chronic hepatitis B. Methods: 70 cases with chronic hepatitis B patients and randomly divided into observation group and control group. The observation group was given recombinant human interferon a-2b,the coures was 12 months. The control group received recombinant human interferon a-2b, the course 6 months. the recovery rate of ALT, HBeAg negative conversion rate and HBeAg / anti HBe serum conversion rate were observed in the two groups . Results:The recovery rate of ALT in the observation group after follow-up of 12hours was higher than that in the control group, the difference was statistically significant(P<0.05). HBeAg negative conversion rate of HBeAg/ anti HBe seroconversion rates in the observation group at the end of treatment, 6 months of follow-up, 12 months of follow-up were compared with those in the control group, the difference was statistically significant (P<0.05). Conclusion:The long course treatment of recombinant human interferon a-2b on chronic hepatitis B has significant effect , the therapy is worthy of reference.