CAJ | 학술논문

目的：评价低钙腹透液和含钙的磷结合剂（碳酸钙）治疗对腹膜透析患者甲状旁腺激素及皮肤瘙痒发病率的影响。探讨纠正腹膜透析患者继发性骨病治疗的新方法。方法：将60例腹膜透析合并皮肤瘙痒患者按照随机原则分为治疗组30例及对照组30例，治疗组使用低钙腹透液（钙浓度1.25mmol/L）和碳酸钙治疗，对照组使用普通钙浓度腹透液（钙浓度1.75mmol/L）治疗，不使用磷结合剂。治疗时间6个月，在实验前和结束后分别测定患者甲状旁腺激素及C反应蛋白激素水平、皮肤瘙痒发病率，评价治疗效果。结果：使用低钙腹透液和碳酸钙治疗6月后，甲状旁腺激素与治疗前后浓度变化有显著性差异（P＜0.05），超敏C反应蛋白浓度变化无显著性差异（P＞0.05）。治疗前后皮肤瘙痒发病率有显著性差异（P＜0.05），对照组患者上述三种指标变化均无显著性差异。结论：低钙腹透液和碳酸钙治疗6月后可以降低甲状旁腺激素浓度水平，可以缓解皮肤瘙痒发病率。
목적：평개저개복투액화함개적린결합제（탄산개）치료대복막투석환자갑상방선격소급피부소양발병솔적영향。탐토규정복막투석환자계발성골병치료적신방법。방법：장60례복막투석합병피부소양환자안조수궤원칙분위치료조30례급대조조30례，치료조사용저개복투액（개농도1.25mmol/L）화탄산개치료，대조조사용보통개농도복투액（개농도1.75mmol/L）치료，불사용린결합제。치료시간6개월，재실험전화결속후분별측정환자갑상방선격소급C반응단백격소수평、피부소양발병솔，평개치료효과。결과：사용저개복투액화탄산개치료6월후，갑상방선격소여치료전후농도변화유현저성차이（P＜0.05），초민C반응단백농도변화무현저성차이（P＞0.05）。치료전후피부소양발병솔유현저성차이（P＜0.05），대조조환자상술삼충지표변화균무현저성차이。결론：저개복투액화탄산개치료6월후가이강저갑상방선격소농도수평，가이완해피부소양발병솔。
Objective:To observe therapy by low-calcium dialysis liquid and phosphor combine to calcium and phosphor metabolize of end-stage renal disease. Probe into the new method of correct turbulence of calcium and phosphor metabolize. Methods:Detach 60 Peritoneal dialysis patients into therapy group 30 cases and comparison group 30 cases by random principle.Therapy group use low-calcium dialysis liquid and phosphor combine,comparison group use normal-calcium dialysis,measure consistence of parathormone and high sensitivity C reaction protein and the skin pruritus rate after 6 months.Statistic analysis and evaluate impact of the treatment. Results:After 6 months of treatment by low-calcium dialysis liquid and calcium carbonate,the consistence of parathormone and the skin pruritus rate has significant difference before and after the experiment.High sensitivity C reaction protein has no significant difference. The consistence of parathormone and the skin pruritus rate has no significant difference of control group. Conclusion:Low-calcium dialysis liquid and phosphor combine can reduce the consistence of parathormone,relief morbidity of the skin pruritus rate.