北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2014年
7期
62-63
,共2页
非酒精性脂肪肝%肠道%肝脏%胆汁酸%外周5-羟色胺系统
非酒精性脂肪肝%腸道%肝髒%膽汁痠%外週5-羥色胺繫統
비주정성지방간%장도%간장%담즙산%외주5-간색알계통
Non-alcoholic fatty liver disease%Intestine%Liver%Bile acids%Peripheral serotonin system
非酒精性脂肪肝涵盖了从脂肪变性、脂肪性肝炎到肝纤维化、肝硬化、肝癌不同阶段的肝脏损伤。研究发现,外周5-羟色胺系统在肝脏脂质代谢方面有着重要作用。本文从肠道、肝脏本身以及胆汁酸肠肝循环方面综述了外周5-羟色胺系统与肝脏脂质代谢的相关性,有望找到非酒精性脂肪肝药物治疗新的研究方向。
非酒精性脂肪肝涵蓋瞭從脂肪變性、脂肪性肝炎到肝纖維化、肝硬化、肝癌不同階段的肝髒損傷。研究髮現,外週5-羥色胺繫統在肝髒脂質代謝方麵有著重要作用。本文從腸道、肝髒本身以及膽汁痠腸肝循環方麵綜述瞭外週5-羥色胺繫統與肝髒脂質代謝的相關性,有望找到非酒精性脂肪肝藥物治療新的研究方嚮。
비주정성지방간함개료종지방변성、지방성간염도간섬유화、간경화、간암불동계단적간장손상。연구발현,외주5-간색알계통재간장지질대사방면유착중요작용。본문종장도、간장본신이급담즙산장간순배방면종술료외주5-간색알계통여간장지질대사적상관성,유망조도비주정성지방간약물치료신적연구방향。
Non-alcoholic fatty liver disease(NAFLD)encompasses a series of liver damage ranging from simple steatosis, steatohepatitis to hepatic fibrosis, cirrhosis and hepatocellular carcinoma. Previous study shows that peripheral serotonin system plays an important role in hepatic lipid metabolism. This article reviewed the correlation between peripheral serotonin system and hepatic lipid metabolism from three aspects:intestine, liver and bile acids. Peripheral serotonin system is expected to be a new target for NAFLD therapy.