中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
9期
53-55,106
,共4页
涂厚义%陈茜%殷泽登
塗厚義%陳茜%慇澤登
도후의%진천%은택등
胰岛素样生长因子-1%感音神经性耳聋%凋亡%信号转导
胰島素樣生長因子-1%感音神經性耳聾%凋亡%信號轉導
이도소양생장인자-1%감음신경성이롱%조망%신호전도
Insulin-like growth factor 1%Sensorineural hearing loss%Apoptosis%Signal transduction
感音神经性耳聋是耳鼻咽喉科常见病，耳蜗细胞凋亡是感音神经性耳聋的主要原因之一。IGF-1通过多种信号转导途径激活细胞周期和抑制细胞凋亡，从而参与耳蜗细胞正常的生长、发育和分化，以及在耳蜗细胞损伤时参与维持细胞的存活和修复。IGF-1局部应用对于治疗突发性聋、药物性聋等感音神经性聋方面的研究取得了进展。
感音神經性耳聾是耳鼻嚥喉科常見病，耳蝸細胞凋亡是感音神經性耳聾的主要原因之一。IGF-1通過多種信號轉導途徑激活細胞週期和抑製細胞凋亡，從而參與耳蝸細胞正常的生長、髮育和分化，以及在耳蝸細胞損傷時參與維持細胞的存活和脩複。IGF-1跼部應用對于治療突髮性聾、藥物性聾等感音神經性聾方麵的研究取得瞭進展。
감음신경성이롱시이비인후과상견병，이와세포조망시감음신경성이롱적주요원인지일。IGF-1통과다충신호전도도경격활세포주기화억제세포조망，종이삼여이와세포정상적생장、발육화분화，이급재이와세포손상시삼여유지세포적존활화수복。IGF-1국부응용대우치료돌발성롱、약물성롱등감음신경성롱방면적연구취득료진전。
Sensorineural hearing loss is a common disease and apoptosis of cochlear cells is one of the most common causes. Insulin like growth factor-1(IGF-1) activates cell cycle and inhibits apoptosis by diverse signal transduction pathways,plays an important role in the regulation of cochlear growth, development and differentiation,and maintaining cochlear survival and recovery under cochlear cell damage. There were some progresses in the treatments of sudden deafness and drug deafness by local application of IGF-1.
