中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
9期
32-36
,共5页
贾振军%苗新东%臧学良%郭雪洁
賈振軍%苗新東%臧學良%郭雪潔
가진군%묘신동%장학량%곽설길
胃炎%不典型增生%胃癌%Ki67%p16
胃炎%不典型增生%胃癌%Ki67%p16
위염%불전형증생%위암%Ki67%p16
Gastritis%Dysplasia%Gastric cancer%Ki67%p16
目的：分析胃炎组织、不典型增生组织和癌组织中Ki67和p16的表达情况，探讨其与胃组织癌变的关系及作为早期癌变生物学标志的可能性。方法应用免疫组织化学SP法对22例胃炎组织、80例不典型增生组织及6O例胃癌组织中的Ki67和pl6的表达情况进行检测。结果在胃炎组织、不典型增生组织及胃癌组织中Ki67则呈递增趋势，而pl6的表达阳性率呈递减趋势；结果显示Ki67和pl6表达阳性率与胃黏膜组织从胃炎至不典型增生再至癌变这一过程均相关（P＜0.05）。Ki67的表达与胃癌的Lauren分型、浸润深度、淋巴结转移有关，与分化程度无关。Pl6的表达与胃癌的Lauren分型、分化程度、浸润深度无关，与淋巴结转移有关。Ki67和pl6的表达在胃癌组织中呈负相关（P＜0.05）。结论 Ki67和pl6的表达异常与胃癌的癌变过程相关，两者有可能成为胃组织早期癌变的分子标记物。
目的：分析胃炎組織、不典型增生組織和癌組織中Ki67和p16的錶達情況，探討其與胃組織癌變的關繫及作為早期癌變生物學標誌的可能性。方法應用免疫組織化學SP法對22例胃炎組織、80例不典型增生組織及6O例胃癌組織中的Ki67和pl6的錶達情況進行檢測。結果在胃炎組織、不典型增生組織及胃癌組織中Ki67則呈遞增趨勢，而pl6的錶達暘性率呈遞減趨勢；結果顯示Ki67和pl6錶達暘性率與胃黏膜組織從胃炎至不典型增生再至癌變這一過程均相關（P＜0.05）。Ki67的錶達與胃癌的Lauren分型、浸潤深度、淋巴結轉移有關，與分化程度無關。Pl6的錶達與胃癌的Lauren分型、分化程度、浸潤深度無關，與淋巴結轉移有關。Ki67和pl6的錶達在胃癌組織中呈負相關（P＜0.05）。結論 Ki67和pl6的錶達異常與胃癌的癌變過程相關，兩者有可能成為胃組織早期癌變的分子標記物。
목적：분석위염조직、불전형증생조직화암조직중Ki67화p16적표체정황，탐토기여위조직암변적관계급작위조기암변생물학표지적가능성。방법응용면역조직화학SP법대22례위염조직、80례불전형증생조직급6O례위암조직중적Ki67화pl6적표체정황진행검측。결과재위염조직、불전형증생조직급위암조직중Ki67칙정체증추세，이pl6적표체양성솔정체감추세；결과현시Ki67화pl6표체양성솔여위점막조직종위염지불전형증생재지암변저일과정균상관（P＜0.05）。Ki67적표체여위암적Lauren분형、침윤심도、림파결전이유관，여분화정도무관。Pl6적표체여위암적Lauren분형、분화정도、침윤심도무관，여림파결전이유관。Ki67화pl6적표체재위암조직중정부상관（P＜0.05）。결론 Ki67화pl6적표체이상여위암적암변과정상관，량자유가능성위위조직조기암변적분자표기물。
Objective To analyze the expression situation of Ki67 and p16 in gastritis tissue, dysplasia tissue and cancer tissue and explore their relationship to gastric tissue canceration and their possibility of being biological markers of early canceration. Methods The immunohistochemical SP method was used to detect the expression situation of Ki67 and p16 in 22 cases of gastritis tissue,80 cases of dysplasia tissue and 60 cases of cancer tissue. Results In gastritis tissue, dysplasia tissue and cancer tissue,Ki67 presented an ascending trend and the positive expression rate of p16 presented a descending trend.The results showed that the positive expression rates of Ki67 and p16 and the gastric mucosal tissue were correlated to each other from gastric cancer to dysplasia and from dysplasia to canceration(P < 0.05).The expression of Ki67 was correlated to the Lauren typing,invasion depth and lymphatic metastasis of gastric cancer,but not correlated to the differentiation degree.The expression of p16 was correlated to the Lauren typing, differentiation degree and invasion depth of gastric cancer,but not correlated to the lymphatic metastasis. The expression of Ki67 and p16 in gastric cancer tissue were negatively correlated(P<0.05). Conclusion The abnormal expression of Ki67 and p16 relates to the canceration process of gastric cancer and both may become the molecular markers of the early canceration of gastric tissue.
