CAJ | 학술논문

目的：通过研究星状神经节阻滞（SGB）对于大鼠乳腺增生模型激素水平的调节，进一步探讨其对乳腺增生的影响机制。方法选取40只成年雌性未孕 Wistar 大鼠随机分成空白对照组、乳腺增生模型组、乳癖消组，乳癖消联合 SGB 组。对比分析各组大鼠的乳房直径、乳头高度、血清雌二醇（E2）、黄体酮（P）、催乳素（PRL）水平等指标。结果乳癖消联合 SGB 组大鼠的 E2、PRL 水平下降程度及 P 水平提高程度与乳癖组相比有显著性差异（P ＜0．05）。结论对于大鼠乳腺增生模型的干预中，联合应用 SGB 治疗能够有效调节其激素水平，明显减小乳房直径和乳头高度，达到更加有效的治疗效果。
목적：통과연구성상신경절조체（SGB）대우대서유선증생모형격소수평적조절，진일보탐토기대유선증생적영향궤제。방법선취40지성년자성미잉 Wistar 대서수궤분성공백대조조、유선증생모형조、유벽소조，유벽소연합 SGB 조。대비분석각조대서적유방직경、유두고도、혈청자이순（E2）、황체동（P）、최유소（PRL）수평등지표。결과유벽소연합 SGB 조대서적 E2、PRL 수평하강정도급 P 수평제고정도여유벽조상비유현저성차이（P ＜0．05）。결론대우대서유선증생모형적간예중，연합응용 SGB 치료능구유효조절기격소수평，명현감소유방직경화유두고도，체도경가유효적치료효과。
Objective To further explore the function mechanism of stellate ganglion block (SGB)on hormone level in rats with breast hyperplasia.Methods A total of 40 female rats were divided into four groups randomly:blank control group,model group (with breast hyperplasia), treatment group (with Rubixiao)and combined group (Rupixiao combined with SGB).The diame-ter of breast,the height of papilla,the levels of estradiol (E2 ),progesterone (P)and prolactin (PRL)were compared between two groups.Results The difference was significant in the de-creased level of E2 and PRL as well as increased P level between combined group and treatment group (P <0.05).Conclusion In the intervention of rats with breast hyperplasia,combined appli-cation of SGB can effectively regulate the hormone level and reduce the diameter of breast and the height of papilla so as to achieve more superior efficacy.