CAJ | 학술논문

目的：探讨南通地区不同年龄过敏儿童的过敏原的种类。方法采用体外特异性过敏原检测系统和全自动免疫发光仪对本院儿童医院门诊及住院的218例患儿按不同年龄进行血清过敏原特异性 lgE（slgE）抗体和总 lgE 检测，同时还对28例过敏患儿进行了体内试验（皮肤点刺）与体外试验（血清特异性过敏原）的比较。结果218例过敏患儿中，吸入性过敏114例（52．4％），食入性过敏101例（46．3％）；不同年龄组过敏原有所不同，婴幼儿组（＜3岁）食入性过敏45例（51．1％），吸入性过敏17例（19．3％），二者有显著差异（P ＜0．01）；儿童组（＞3～12岁）吸入性过敏57例（58．2％），而食入性过敏47例（47．9％），二者无显著差异（P ＞0．05）；少年组（＞12岁）吸入性过敏16例（50％），而食入性过敏12例（37．5％），二者差异有统计学意义（P ＜0．05）。28例体内试验与体外试验的比较，两种方法的敏感性与特异性以及 ROC 曲线等诊断特性参数比较无统计学意义（P ＞0．05）。结论婴幼儿期以食入性过敏为主，少年组以吸入性过敏为主，儿童期吸入性和食入性过敏无明显差异，食入性以鸡蛋和海产品为主，吸入性以尘螨、屋尘为主。
목적：탐토남통지구불동년령과민인동적과민원적충류。방법채용체외특이성과민원검측계통화전자동면역발광의대본원인동의원문진급주원적218례환인안불동년령진행혈청과민원특이성 lgE（slgE）항체화총 lgE 검측，동시환대28례과민환인진행료체내시험（피부점자）여체외시험（혈청특이성과민원）적비교。결과218례과민환인중，흡입성과민114례（52．4％），식입성과민101례（46．3％）；불동년령조과민원유소불동，영유인조（＜3세）식입성과민45례（51．1％），흡입성과민17례（19．3％），이자유현저차이（P ＜0．01）；인동조（＞3～12세）흡입성과민57례（58．2％），이식입성과민47례（47．9％），이자무현저차이（P ＞0．05）；소년조（＞12세）흡입성과민16례（50％），이식입성과민12례（37．5％），이자차이유통계학의의（P ＜0．05）。28례체내시험여체외시험적비교，량충방법적민감성여특이성이급 ROC 곡선등진단특성삼수비교무통계학의의（P ＞0．05）。결론영유인기이식입성과민위주，소년조이흡입성과민위주，인동기흡입성화식입성과민무명현차이，식입성이계단화해산품위주，흡입성이진만、옥진위주。
Objective To explore the types of allergen in allergic children with different age in Nantong region.Methods Serum allergen test system was used to detect specific IgE and total IgE in 218 cases,and skin prick and serum immune strap mark experiment were used in 28 cases. Results Allergen of inhalation was observed in 114 cases(52.4%)and food allergen was observed in 101 cases(46.3%),and there were significant differences in different age groups.Aeroallergen was observed in 17 cases(19.3%)and food allergen was observed in 45 cases(51.1%)in infant groups,and there was significant difference (P <0.01 ),but there was no significant difference in child group(P >0.05 ).In the elder children,there were significant differences (P <0.05 )of aeroallergen and food allergen.There were no significant difference of sensitivity and specificity be-tween skin prick test and serum immune strap mark experiment (P >0.05).Conclusion The food allergen is the most common allergen in infants and the aeroallergen is the common allergen in teen-age.The main food allergens are egg and sea food,the main aeroallergens are dust mites and house dust.