CAJ | 학술논문

目的：探讨米氮平和舍曲林治疗老年抑郁症的疗效及安全性。方法：将60例首发老年抑郁症患者(年龄≥60岁)随机分成两组,每组30例。两组患者分别应用米氮平和舍曲林治疗8周,采用汉密尔顿抑郁量表( HAMD )、汉密尔顿焦虑量表( HAMA )、副反应量表(TESS)评定疗效和不良反应。结果：治疗后两组患者HAMD和HAMA评分较治疗前均有显著下降(P＜0.01)。两组患者间比较,1周末和2周末米氮平组HAMD和HAMA评分减分较舍曲林组有显著差异(P＜0.05),4周末和8周末评分,两组无显著差异(P＞0.05)。苯二氮类药物使用舍曲林组患者显著多于米氮平组(P＜0.01)。不良反应：舍曲林组患者恶心、睡眠及性功能障碍显著多于米氮平组(P＜0.01)；而米氮平组患者食欲增加和体质量增显著多于舍曲林组(P＜0.05)。结论：米氮平和舍曲林治疗老年抑郁症疗效相当,而米氮平起效更快,不良反应少,依从性高,更适宜老年患者。
목적：탐토미담평화사곡림치료노년억욱증적료효급안전성。방법：장60례수발노년억욱증환자(년령≥60세)수궤분성량조,매조30례。량조환자분별응용미담평화사곡림치료8주,채용한밀이돈억욱량표( HAMD )、한밀이돈초필량표( HAMA )、부반응량표(TESS)평정료효화불량반응。결과：치료후량조환자HAMD화HAMA평분교치료전균유현저하강(P＜0.01)。량조환자간비교,1주말화2주말미담평조HAMD화HAMA평분감분교사곡림조유현저차이(P＜0.05),4주말화8주말평분,량조무현저차이(P＞0.05)。분이담류약물사용사곡림조환자현저다우미담평조(P＜0.01)。불량반응：사곡림조환자악심、수면급성공능장애현저다우미담평조(P＜0.01)；이미담평조환자식욕증가화체질량증현저다우사곡림조(P＜0.05)。결론：미담평화사곡림치료노년억욱증료효상당,이미담평기효경쾌,불량반응소,의종성고,경괄의노년환자。
Objective:To explore and study the efficacy and safety of Mirtazapine and Sertraline in treatment of geriatric de-pression. Methods:60 old patients (≥60 years old) suffering from first-episode depression were randomly divided into two groups (30 patients in each group). The two groups were treated with Mirtazapine and Sertraline for eight weeks, respectively. Hamilton's de-pression scale ( HAMD) , Hamilton anxiety scale ( HAMA) and treatment emergent symptom scale ( TESS) were used to evaluate the efficacy and the side effects. Results:After the treatment, the scores of HAMD and HAMA of the two groups both decreased greatly ( P<0. 01). On the first and second weekends of the treatment, there were significant differences in the decrease of the scores of HAMD and HAMA between Mirtazapine group and Sertraline group (P<0. 05);however, on the fourth and eighth weekends of the treatment, there were no differences in the decrease of the scores of HAMD and HAMA between Mirtazapine group and Sertraline group ( P>0. 05). The use of benzodiazepines of Sertraline group was significantly more than that of Mirtazapine group (P<0. 01). For the side effects, nausea, sleep and sexual dysfunction of the Sertraline group were more than those of the Mirtazapine group (P<0. 01);while increased appetite and weights of Sertraline group were lower than those of the Mirtazapine group (P<0. 05). Conclusions:Mirtazapine and Sertraline have the equivalent therapeutic effects in the treatment of geriatric depression, while Mirtazapine works faster with fewer adverse reactions and higher compliance, so it is more suitable for the elderly patients.