CAJ | 학술논문

目的：探讨氟伏沙明对精神分裂症患者伴发强迫症状的疗效。方法：精神分裂症伴强迫症状患者60例,随机分为研究组(氟伏沙明合并奥氮平组)和对照组(奥氮平组)各30例。患者于治疗前及治疗后8周末应用阳性和阴性症状量表( PANSS)、耶鲁-布朗强迫症状量表(Y-BOCS)和副反应量表(TESS)评定疗效及不良反应。结果：治疗后,研究组患者较对照组 PANSS、Y-BOCS 评分下降更显著(P＜0.01),TESS评分无显著差异(P＞0.05)。结论：氟伏沙明结合抗精神病药物治疗较单用抗精神病药物治疗能提高伴发强迫症状的精神分裂症患者的疗效。
목적：탐토불복사명대정신분렬증환자반발강박증상적료효。방법：정신분렬증반강박증상환자60례,수궤분위연구조(불복사명합병오담평조)화대조조(오담평조)각30례。환자우치료전급치료후8주말응용양성화음성증상량표( PANSS)、야로-포랑강박증상량표(Y-BOCS)화부반응량표(TESS)평정료효급불량반응。결과：치료후,연구조환자교대조조 PANSS、Y-BOCS 평분하강경현저(P＜0.01),TESS평분무현저차이(P＞0.05)。결론：불복사명결합항정신병약물치료교단용항정신병약물치료능제고반발강박증상적정신분렬증환자적료효。
Objective:To explore efficacy of Fluvoxamine in treatment of patients with schizophrenia combined with obsessive-compulsive symptoms. Methods:60 patients with schizophrenia combined with obsessive-compulsive symptoms were randomly divided into study group (30 cases, treated with Fluvoxamine plus olanzapine) and control group (30 cases, treated with olanzapine). The curative effect was assessed by using positive and negative symptom scale ( PANSS ) , Yale-Brown obsessive-compulsive scale (YBOCS) and adverse reactions was assessed by using treatment emergent symptom scale (TESS) at baseline and at the 8th weekend of the treatment. Results:After the treatment, the decrease of PANSS and YBOCS scores in study group was more obvious than that in control group (P<0. 01), while score of TESS was insignificant between the two groups(P>0. 05). Conclusions: Fluvoxamine com-bined with antipsychotic drugs has better effects than single antipsychotic drugs for the patients with schizophrenia combined with ob-sessive-compulsive symptoms.