CAJ | 학술논문

目的：探讨吡格列酮对不稳定型心绞痛治疗的有效性、安全性和预防心脑血管事件的价值。方法将114例不稳定型心绞痛患者分为2组：治疗组68例，不稳定型心绞痛常规治疗＋吡格列酮15mg，每日1次；对照组46例，按不稳定型心绞痛常规治疗。随访1年，观察2组抗心绞痛疗效、心电图改善情况、心脑血管事件及不良反应发生情况。结果治疗组与对照组相比较，能显著改善心绞痛症状（总有效率分别为84％与65％），改善心绞痛的缺血心电图（总有效率分别为91％与78％）；治疗组随访1年中复发性心绞痛、心力衰竭均较对照组明显降低（P＜0.05），且吡格列酮治疗后不良反应少。结论不稳定型心绞痛应用吡格列酮安全有效，可预防心脑血管事件发生。
목적：탐토필격렬동대불은정형심교통치료적유효성、안전성화예방심뇌혈관사건적개치。방법장114례불은정형심교통환자분위2조：치료조68례，불은정형심교통상규치료＋필격렬동15mg，매일1차；대조조46례，안불은정형심교통상규치료。수방1년，관찰2조항심교통료효、심전도개선정황、심뇌혈관사건급불량반응발생정황。결과치료조여대조조상비교，능현저개선심교통증상（총유효솔분별위84％여65％），개선심교통적결혈심전도（총유효솔분별위91％여78％）；치료조수방1년중복발성심교통、심력쇠갈균교대조조명현강저（P＜0.05），차필격렬동치료후불량반응소。결론불은정형심교통응용필격렬동안전유효，가예방심뇌혈관사건발생。
Objective To observe the efficacy and safety of pioglitazone in treating unstable angina (UA)and to evaluate its effect on preventing cardiocerebral vascular events .Methods One hundred and fourteen cases with unstable angina were randomly divided into pioglitazone group (n=68)and control group (n=46) .The patients in pioglitazone group received routine anti-UA treatment and pioglitazone(15 mg 1 times a day) .The patients in con-trol group were treated by routine anti-UA treatment .The efficacy of anti-UA ,the change of ECG and cruor-in-dex ,the incidence of cardiocerebral vascular events and side effect were observed and evaluated during the follow-up of one year .Results Pioglitazone could significantly improve the symptoms of angina pectoris .The total effec-tive rate in pioglitazone group and control group were 84% and 65% ,respectively(P<0.05) .Pioglitazone could also significantly improve ischemia ST-T changes in ECG .The total effective rate in pioglitazone group and control group were 91% and 78% ,respectively(P<0.05) .The incidence of recurrent angina pectoris and heart failure ra-tio of pioglitazone group were less than those in control group (P<0.05) .The side effect of pioglitazone group was less than that of control group .Conclusion Pioglitazone is effective and safe in treating UAP .It could pre-vent the occurrence of cardiocerebral vascular events .