CAJ | 학술논문

目的观察短期胰岛素泵强化治疗对不同病程2型糖尿病（T2D M）患者胰岛β细胞功能的影响。方法收集T2D M患者183例，分为Ⅰ组（新诊断且未接受治疗的T2D M）60例、Ⅱ组（病程≤3年）60例及Ⅲ组（病程＞3年）63例。所有患者均采用短期胰岛素泵强化治疗，比较治疗前后空腹血糖、餐后2 h血糖、C肽、β细胞功能指数（Homa-β）改善率、胰岛素抵抗指数（Homa-IR）改善率。结果各组患者治疗后空腹血糖、餐后2 h血糖及空腹C肽均获得显著改善，与治疗前相比差异均有统计学意义（P均＜0.05）。治疗后各组β细胞功能及胰岛素抵抗均获得显著改善，各组间Homa-β及Homa-IR改善率差异有统计学意义（P均＜0.05）。结论短期胰岛素泵强化治疗可以有效控制不同病程患者的血糖，并且对于β细胞恢复及逆转胰岛素抵抗具有一定作用；患者病程越短，上述作用越明显。因此，建议有条件的T2DM患者，尽早采用短期胰岛素泵强化治疗。
목적관찰단기이도소빙강화치료대불동병정2형당뇨병（T2D M）환자이도β세포공능적영향。방법수집T2D M환자183례，분위Ⅰ조（신진단차미접수치료적T2D M）60례、Ⅱ조（병정≤3년）60례급Ⅲ조（병정＞3년）63례。소유환자균채용단기이도소빙강화치료，비교치료전후공복혈당、찬후2 h혈당、C태、β세포공능지수（Homa-β）개선솔、이도소저항지수（Homa-IR）개선솔。결과각조환자치료후공복혈당、찬후2 h혈당급공복C태균획득현저개선，여치료전상비차이균유통계학의의（P균＜0.05）。치료후각조β세포공능급이도소저항균획득현저개선，각조간Homa-β급Homa-IR개선솔차이유통계학의의（P균＜0.05）。결론단기이도소빙강화치료가이유효공제불동병정환자적혈당，병차대우β세포회복급역전이도소저항구유일정작용；환자병정월단，상술작용월명현。인차，건의유조건적T2DM환자，진조채용단기이도소빙강화치료。
Objective To observe the influence of short-term intensive treatment on pancreatic function by insulin pump to Type 2 Diabetes Mellitus (T2DM) with different course of disease. Methods 183 cases of T2DM were col ected and divided into GroupⅠ(60 cases, new diagnosed and without any treatment), GroupⅡ(60 cases, course of disease≤3 years) and GroupⅢ(63 cases, course of disease>3 years). All the patients accepted intensive treatment by insulin pump. We compared the fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2 h PG), C-peptide, the improvement rate of Homa-βand Homa-IR. Results The FPG, 2 h PG, C-peptide were improved in each group compared to those before the treatment (All P<0.05). The function ofβcells and insulin resistance were improved in each group after the treatment with statistical significance (All P<0.05). Conclusion Short-term intensive treatment by insulin pump could improve the function ofβcells and insulin resistance in pancreas. The patients with shorter course of disease could benefit more from it. So, we suggest that the patients with T2DM should accepted short-term intensive treatment by insulin pump if it is possible.