CAJ | 학술논문

目的：探讨急性脑梗死患者血栓前状态（Pts）血浆纤维蛋白原(fiB)含量和血液流变学指标的变化。方法用全自动血凝仪和全自动血液流变分析仪分别检测402例急性脑梗死患者发病24小时内及384例健康对照组血浆纤维蛋白原(fiB)含量和全血粘度（高切200s/mpa.s 低切5s/mpa.s）血浆粘度、红细胞聚集指数。结果急性脑梗死患者血浆纤维蛋白原(fiB)含量和全血粘度（高切200s/mpa.s 低切5s/mpa.s）血浆粘度、红细胞聚集指数明显增高，与健康对照组比较有非常显著差异（P <0.05）。结论血浆纤维蛋白原(fiB)含量和血液流变学指标的测定可以作为脑梗死患者血栓前状态初筛实验。
목적：탐토급성뇌경사환자혈전전상태（Pts）혈장섬유단백원(fiB)함량화혈액류변학지표적변화。방법용전자동혈응의화전자동혈액류변분석의분별검측402례급성뇌경사환자발병24소시내급384례건강대조조혈장섬유단백원(fiB)함량화전혈점도（고절200s/mpa.s 저절5s/mpa.s）혈장점도、홍세포취집지수。결과급성뇌경사환자혈장섬유단백원(fiB)함량화전혈점도（고절200s/mpa.s 저절5s/mpa.s）혈장점도、홍세포취집지수명현증고，여건강대조조비교유비상현저차이（P <0.05）。결론혈장섬유단백원(fiB)함량화혈액류변학지표적측정가이작위뇌경사환자혈전전상태초사실험。
Objective to explore characteristics of prethrombotic state of acute cerebral infarction(aci) by measuring levels of plasma fibrinogen and rheological indices. Methods Plasma fibrinogen, whole blood viscosity (high and low shear), plasma viscosity, and erythrocyte aggregation index were measured by using full automatic blood coagulation analyzer and full automatic blood viscosity analyzer in 402 aci within 24 hours of onset subjects and in 384 healthy control subjects. Results Plasma fibrinogen, whole blood viscosity (high shear 200 s/mpa.s and low shear 5s/mpa.s ), plasma viscosity, and erythrocyte aggregation index in ACI subjects markedly increased as compared with the healthy control subjects with statistically significant difference (P <0.05). Conclusion Determination of levels of plasma fibrinogen and blood rheological indices may be utilized as screening test for the prethombotic state of aci.