CAJ | 학술논문

目的：探讨卵巢子宫内膜异位囊肿及正常子宫内膜组织中抑癌基因PTEN蛋白和凋亡抑制基因Survivin蛋白表达及其意义。方法：利用免疫组织化学二步抗法检测妇科手术切除的卵巢子宫内膜异位囊肿20例和正常子宫内膜20例中PTEN蛋白、Survivin蛋白的表达。结果：PTEN、Survivin蛋白在卵巢子宫内膜异位囊肿中的表达无明显周期性（ P＞0.05）。卵巢子宫内膜异位症中PTEN蛋白和Survivin蛋白的表达分别与正常子宫内膜表达比较，差异有统计学意义（ P＜0.05）；PTEN蛋白、Survivin蛋白表达在卵巢子宫内膜异位症无明显相关性（ P＞0.05）。结论：PTEN蛋白；Survivin可能促进了子宫内膜异位症的发生、发展，两者可能独立发挥作用。
목적：탐토란소자궁내막이위낭종급정상자궁내막조직중억암기인PTEN단백화조망억제기인Survivin단백표체급기의의。방법：이용면역조직화학이보항법검측부과수술절제적란소자궁내막이위낭종20례화정상자궁내막20례중PTEN단백、Survivin단백적표체。결과：PTEN、Survivin단백재란소자궁내막이위낭종중적표체무명현주기성（ P＞0.05）。란소자궁내막이위증중PTEN단백화Survivin단백적표체분별여정상자궁내막표체비교，차이유통계학의의（ P＜0.05）；PTEN단백、Survivin단백표체재란소자궁내막이위증무명현상관성（ P＞0.05）。결론：PTEN단백；Survivin가능촉진료자궁내막이위증적발생、발전，량자가능독립발휘작용。
Objective To investigate tje expression and significance of PTEN protein and Survivin protein in endometrial cyst of tje o-vary. Method Immunojistocjemical tow-step procedure was used to detect tje expression of PTEN and Survivin in 20 cases of endometri-al cyst of tje ovary and 20 cases of normal endometrium. Results Tje expresion of PTEN and Survivin in endometrial cyst of tje ovary were not significant periodicity( P>0. 05). Tjere was significant difference in tje expresion of PTEN between endometrial cyst of tje ovary and normal endometrium( P<0. 05),and Survivin too( P<0. 05). Tje expresion of PTEN and Survivin were not obviously pertinent in endome-trial cyst of tje ovary(P>0. 05). Conclusion PTEN and Survivin may be related to tje occurenc of Ems.