CAJ | 학술논문

目的探讨免疫性粒细胞减少症的诊断及治疗.方法收集150例住院及门诊免疫性中性粒细胞减少症患者临床资料.利用SPSS 13.0进行数据的统计分析.结果 150例患者中,男性35例(23.3％),女性115例(76.7％),男女之比为1∶3.3.依据中性粒细胞抗体产生方式不同分为新生儿同种免疫性中性粒细胞减少症9例(6.0％)；药物性免疫粒细胞减少症28例(18.7％)；原发性自身免疫性中性粒细胞减少症22例(14.6％)；继发性免疫性粒细胞减少症91例(60.7％):包括系统性红斑狼疮39例、类风湿关节炎21例、免役性溶血伴粒细胞减少2例、免疫性血小板减少症伴粒细胞减少6例、免疫性肝炎3例、免疫性甲状腺炎16例、干燥综合征4例.结论免疫性中性粒细胞减少症以女性居多,常继发于某些自身免疫性疾病.原发性自身免疫性中性粒细胞减少症诊断较为复杂,需长时间临床观察和随访.免疫性中性粒细胞减少症患者的中性粒细胞抗体以IgG为主,有的表现两种或三种抗体同时升高.
목적 탐토면역성립세포감소증적진단급치료.방법 수집150례주원급문진면역성중성립세포감소증환자림상자료.이용SPSS 13.0진행수거적통계분석.결과 150례환자중,남성35례(23.3％),녀성115례(76.7％),남녀지비위1∶3.3.의거중성립세포항체산생방식불동분위신생인동충면역성중성립세포감소증9례(6.0％)；약물성면역립세포감소증28례(18.7％)；원발성자신면역성중성립세포감소증22례(14.6％)；계발성면역성립세포감소증91례(60.7％):포괄계통성홍반랑창39례、류풍습관절염21례、면역성용혈반립세포감소2례、면역성혈소판감소증반립세포감소6례、면역성간염3례、면역성갑상선염16례、간조종합정4례.결론 면역성중성립세포감소증이녀성거다,상계발우모사자신면역성질병.원발성자신면역성중성립세포감소증진단교위복잡,수장시간림상관찰화수방.면역성중성립세포감소증환자적중성립세포항체이IgG위주,유적표현량충혹삼충항체동시승고.
Objective To explore the diagnosis and of immune neutopenia.Methods Clinical data of 150 patients with immune neutropenia were collected and analyzed.Results Of 150 patients with immune neutropenia,35 cases went male(23.3％),115 cases were female(76.7％),and male to female ratio was 1 ∶ 3.3.Based on the difference produced way of granulocytes associated antibody,all patients could be divided into alloimmune neonatal neutropenia 9 cases (6.0％),drug-induced immune neutropenia 28 cases (18.7 ％),primary autoimmune neutropenia 22 cases(14.6％),and secondary autoimmune neutropenia 91 cases (60.7％).Secondary autoimmune neutropenia included 39 cases of systemic lupus erythematous,21 cases of rheumatoid arthritis,2 cases of immune hemolytic anemia accompany with neutropenia,6 cases of immune thrombocytopenia accompany with neutropenia,3 cases of autoimmune hepatitis,16 cases of autoimmune thyroiditis,and 4 cases of Sjogren's syndrome.Conclusion The majority of primary immune neutropenia are female,which is usually secondary to autoimmune diseases.The diagnosis of primary immune neutropenia is very complicated,which requires a long period of clinical observation and follow-up.The majority of granulocytes associated antibody is IgG in the autoimmune neutropenia patients.Yet sometimes two or three kinds of antibodies were increased as well.