中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2013年
24期
1487-1491
,共5页
刘慧龙%李虹义(综述)%刘端祺(审校)
劉慧龍%李虹義(綜述)%劉耑祺(審校)
류혜룡%리홍의(종술)%류단기(심교)
阿片药物%纳络酮%癌痛%便秘
阿片藥物%納絡酮%癌痛%便祕
아편약물%납락동%암통%편비
opioids%naloxone%cancer pain%constipation
纳洛酮是一种人工合成的阿片受体拮抗剂，可以拮抗和逆转阿片药物的全部药理作用，是阿片药物过量救治的标准药物和特效治疗药物，用于治疗阿片药物过量所致的昏迷和呼吸抑制。近年研究显示，纳洛酮在缓解长期应用阿片药物所致便秘方面，也有突出的疗效。还有研究发现，应用超低剂量纳洛酮可以增强阿片药物止痛效果，减少阿片药物消耗量。本文对纳洛酮在癌痛治疗中的这些应用与研究进展进行综述。
納洛酮是一種人工閤成的阿片受體拮抗劑，可以拮抗和逆轉阿片藥物的全部藥理作用，是阿片藥物過量救治的標準藥物和特效治療藥物，用于治療阿片藥物過量所緻的昏迷和呼吸抑製。近年研究顯示，納洛酮在緩解長期應用阿片藥物所緻便祕方麵，也有突齣的療效。還有研究髮現，應用超低劑量納洛酮可以增彊阿片藥物止痛效果，減少阿片藥物消耗量。本文對納洛酮在癌痛治療中的這些應用與研究進展進行綜述。
납락동시일충인공합성적아편수체길항제，가이길항화역전아편약물적전부약리작용，시아편약물과량구치적표준약물화특효치료약물，용우치료아편약물과량소치적혼미화호흡억제。근년연구현시，납락동재완해장기응용아편약물소치편비방면，야유돌출적료효。환유연구발현，응용초저제량납락동가이증강아편약물지통효과，감소아편약물소모량。본문대납락동재암통치료중적저사응용여연구진전진행종술。
Naloxone is a synthetic pan-opioid receptor competitive antagonist of the opioid receptors inside and outside the cen-tral nervous system. After systemic administration, it reverses almost all opioid effects. Systemically administered naloxone is used to reverse the life-threatening opioid toxicity. A number of studies have analyzed the importance of oral naloxone as a peripheral opioid an-tagonist in cancer patients. Naloxone has shown satisfactory efficacy for opioid-induced constipation (OIC). Ultra-low dose of naloxone has been reported to enhance the anti-nociceptive effect of morphine and reduce morphine consumption. We summarize the results from current studies of naloxone administration in cancer pain management.
