CAJ | 학술논문

目的探讨泽漆水提液对小鼠S180肉瘤的抑制作用。方法采用环磷酰胺作阳性对照，通过计算抑瘤率、胸腺指数及脾指数观察泽漆对小鼠肉瘤的抑制作用，用丙二醛（MDA）、超氧化物歧化酶（SOD）联合测定法初步分析泽漆抗肿瘤的的机制。结果泽漆提取液能抑制小鼠S180肉瘤的生长、升高小鼠脾指数及胸腺指数，能增加SOD的活性，高剂量组作用最明显，给药后小鼠血浆中MDA的含量有所降低。结论泽漆提取液抗肿瘤作用与降低体内脂质过氧化反应、清除体内过多自由基，以及增强机体免疫力有关。
목적탐토택칠수제액대소서S180육류적억제작용。방법채용배린선알작양성대조，통과계산억류솔、흉선지수급비지수관찰택칠대소서육류적억제작용，용병이철（MDA）、초양화물기화매（SOD）연합측정법초보분석택칠항종류적적궤제。결과택칠제취액능억제소서S180육류적생장、승고소서비지수급흉선지수，능증가SOD적활성，고제량조작용최명현，급약후소서혈장중MDA적함량유소강저。결론택칠제취액항종류작용여강저체내지질과양화반응、청제체내과다자유기，이급증강궤체면역력유관。
Objective To study the inhibition effect of Euphorbia helioscopia water extraction on S180 tumor in mice. Methods Using cyclophosphamide as the positive control, the calculations of inhibitory rate, thymus index and spleen index were determined by weight to observe the inhibition effect on S180. The malondialdehyde(MDA)and Objective To study the inhibition effect of Euphorbia helioscopia water extraction on S180 tumor in mice. Methods Using cyclophosphamide as the positive control, the calculations of inhibitory rate, thymus index and spleen index were determined by weight to observe the inhibition effect on S180. The malondialdehyde(MDA)and superoxide dismutase(SOD)were determined to preliminarily analyze the antineoplastic mechanism of Euphorbia helioscopia. Results Euphorbia helioscopia water extraction inhibited the growth of S180 in mice, increased the spleen index and thymus index, increased the SOD activity, especially in high dose group. After the treatment, the MDA content was reduced. Conclusion The anti-tumor effect of Euphorbia helioscopia may have a relationship with reducing the body lipid peroxidation, ridding the excess of free radicals in body, and enhancing immunity.