食品与药品
食品與藥品
식품여약품
FOOD AND DRUG
2013年
5期
311-313
,共3页
参丹滴丸%心肌缺血%异丙肾上腺素%心电图J点%心电图T波
參丹滴汍%心肌缺血%異丙腎上腺素%心電圖J點%心電圖T波
삼단적환%심기결혈%이병신상선소%심전도J점%심전도T파
Shendan Drop Pills%myocardial ischemia%isoproterenol%J point of ECG%T wave of ECG
目的研究参丹滴丸对盐酸异丙肾上腺素(ISO)诱导大鼠急性心肌缺血的保护作用。方法采用大鼠皮下多点注射ISO(2 mg/kg),观察参丹滴丸对大鼠注射ISO后不同时间点心电图(ECG)J点及T波下移的影响;采用大鼠急性心肌损伤模型,探讨参丹滴丸对血清天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)活性和心肌组织中丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性的影响。结果参丹滴丸各剂量组均可明显改善ISO引起的大鼠心电图J点及T波下移变化(P<0.05或P<0.01);均可不同程度降低AST、LDH、CK、MDA水平,提高SOD活性(P<0.05或P<0.01)。结论参丹滴丸对ISO诱导大鼠心肌缺血模型具有明显的保护作用。
目的研究參丹滴汍對鹽痠異丙腎上腺素(ISO)誘導大鼠急性心肌缺血的保護作用。方法採用大鼠皮下多點註射ISO(2 mg/kg),觀察參丹滴汍對大鼠註射ISO後不同時間點心電圖(ECG)J點及T波下移的影響;採用大鼠急性心肌損傷模型,探討參丹滴汍對血清天鼕氨痠轉氨酶(AST)、乳痠脫氫酶(LDH)、肌痠燐痠激酶(CK)活性和心肌組織中丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性的影響。結果參丹滴汍各劑量組均可明顯改善ISO引起的大鼠心電圖J點及T波下移變化(P<0.05或P<0.01);均可不同程度降低AST、LDH、CK、MDA水平,提高SOD活性(P<0.05或P<0.01)。結論參丹滴汍對ISO誘導大鼠心肌缺血模型具有明顯的保護作用。
목적연구삼단적환대염산이병신상선소(ISO)유도대서급성심기결혈적보호작용。방법채용대서피하다점주사ISO(2 mg/kg),관찰삼단적환대대서주사ISO후불동시간점심전도(ECG)J점급T파하이적영향;채용대서급성심기손상모형,탐토삼단적환대혈청천동안산전안매(AST)、유산탈경매(LDH)、기산린산격매(CK)활성화심기조직중병이철(MDA)함량、초양화물기화매(SOD)활성적영향。결과삼단적환각제량조균가명현개선ISO인기적대서심전도J점급T파하이변화(P<0.05혹P<0.01);균가불동정도강저AST、LDH、CK、MDA수평,제고SOD활성(P<0.05혹P<0.01)。결론삼단적환대ISO유도대서심기결혈모형구유명현적보호작용。
Objective To investigate the protective effect of Shendan Drop Pills on acute myocardial ischemic injury induced by isoproterenol in rats. Methods Acute myocardial ischemic models were established by hypodermic injection of isoproterenol(2mg/kg). ECG of the rats was recorded in order to observe the effect of Shendan Drop Pills on the descent of J point and T wave. The levels of aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), the content of malondialdehyde (MDA) in serum and the activity of superoxide dismutase (SOD) were determined. Results Shendan Drop Pills could inhibit the descent of J point and T wave of ECG in rat myocardial ischemia induced by isoproterenol (P<0.05, P<0.01). Shendan Drop Pills could obviously inhibit the levels of serum AST, CK, LDH and MDA, and enhance serum SOD activity (P<0.05, P<0.01). Conclusion Shendan Drop Pills can observably ameliorate myocardial ischemic injury induced by isoproterenol in rats.