国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
21期
3149-3152
,共4页
黄芪颗粒%厄贝沙坦%高血压%早期肾损害
黃芪顆粒%阨貝沙坦%高血壓%早期腎損害
황기과립%액패사탄%고혈압%조기신손해
Astragali granules%Irbesartan%Hypertension%Early renal injury
目的 观察黄芪颗粒联合厄贝沙坦治疗高血压早期肾损害的临床疗效.方法 将70例高血压肾病患者随机分为对照组(35例)和观察组(35例),对照组加用厄贝沙坦150mg,1次/日.治疗组除加用厄贝沙坦150 mg,1次/日外,另加用黄芪颗粒4 g,2次/日治疗.疗程3个月,治疗前及治疗后1月、3月复查以下各项指标:血压、血常规、电解质、肝功能、血清肌酐、血尿素氮、尿酸、24 h尿蛋白定量、血、尿β2微球蛋白.结果 和治疗前比较,治疗1月和3月后,对照组和观察组血、尿β2微球蛋白、收缩压、舒张压、尿酸及24h尿蛋白定量均显著下降(P＜0.01).和对照组比较,观察组治疗1月后,24h尿蛋白定量和血、尿β2微球蛋白水平均明显下降(P＜0.05).治疗3月后,24h尿蛋白定量、肌酐、尿酸明显下降(P＜0.05),血、尿β2微球蛋白水平均显著下降(P＜0.01).结论 黄芪颗粒联合厄贝沙坦治疗高血压早期肾损害可有效降低尿蛋白、改善肾功能.
目的 觀察黃芪顆粒聯閤阨貝沙坦治療高血壓早期腎損害的臨床療效.方法 將70例高血壓腎病患者隨機分為對照組(35例)和觀察組(35例),對照組加用阨貝沙坦150mg,1次/日.治療組除加用阨貝沙坦150 mg,1次/日外,另加用黃芪顆粒4 g,2次/日治療.療程3箇月,治療前及治療後1月、3月複查以下各項指標:血壓、血常規、電解質、肝功能、血清肌酐、血尿素氮、尿痠、24 h尿蛋白定量、血、尿β2微毬蛋白.結果 和治療前比較,治療1月和3月後,對照組和觀察組血、尿β2微毬蛋白、收縮壓、舒張壓、尿痠及24h尿蛋白定量均顯著下降(P＜0.01).和對照組比較,觀察組治療1月後,24h尿蛋白定量和血、尿β2微毬蛋白水平均明顯下降(P＜0.05).治療3月後,24h尿蛋白定量、肌酐、尿痠明顯下降(P＜0.05),血、尿β2微毬蛋白水平均顯著下降(P＜0.01).結論 黃芪顆粒聯閤阨貝沙坦治療高血壓早期腎損害可有效降低尿蛋白、改善腎功能.
목적 관찰황기과립연합액패사탄치료고혈압조기신손해적림상료효.방법 장70례고혈압신병환자수궤분위대조조(35례)화관찰조(35례),대조조가용액패사탄150mg,1차/일.치료조제가용액패사탄150 mg,1차/일외,령가용황기과립4 g,2차/일치료.료정3개월,치료전급치료후1월、3월복사이하각항지표:혈압、혈상규、전해질、간공능、혈청기항、혈뇨소담、뇨산、24 h뇨단백정량、혈、뇨β2미구단백.결과 화치료전비교,치료1월화3월후,대조조화관찰조혈、뇨β2미구단백、수축압、서장압、뇨산급24h뇨단백정량균현저하강(P＜0.01).화대조조비교,관찰조치료1월후,24h뇨단백정량화혈、뇨β2미구단백수평균명현하강(P＜0.05).치료3월후,24h뇨단백정량、기항、뇨산명현하강(P＜0.05),혈、뇨β2미구단백수평균현저하강(P＜0.01).결론 황기과립연합액패사탄치료고혈압조기신손해가유효강저뇨단백、개선신공능.
Objective To observe the clinical efficacy of astragali granules combined with irbesartan in the treatment of early renal injury induced by hypertension.Methods 70 patients with hypertensive nephropathy were randomly assigned to receive irbesartan of 150 mg alone once daily(75 patients,control group),or irbesartan of 150 mg once daily plus astragali granules of 4 g twice daily(75 patients,75 patients,study group)for three months.Levels of urinary β2MG,serum β2MG,24-hour urinary protein were detected,and related clinical indicators were observed before and 1 and 3 months after treatment.Results As compared with the baselines,levels of urinary β2MG,serum β2MG,24-hour urinary protein,and uricacid were decreased significantly one month after treatment in the control group(P＜0.05)and study group(P＜0.01),and were remarkably declined three months after treatment in both groups(P＜0.01).As compared with the control group,levels of urinary β2MG,serum β2MG,and 24-hour urinary protein were decreased significantly one month after treatment in study group(P＜0.05);,levels of 24-hour urinary protein,creatinine,and uric acid were decreased significantly three months after treatment in the study group(P＜0.05)and levels of urinary and serum β2MG were remarkably decreased(P＜0.01).Conclusions Astragali granules combined with irbesartan for early renal injury induced by hypertension.is more effective in reducing urinary protein and improving renal function.
