CAJ | 학술논문

为建立复方血栓通胶囊中4个有效成分的一测多评定量方法，采用高效液相色谱法，以人参皂苷Rg 1为参照对照品，计算其与三七皂苷R1、人参皂苷Re、人参皂苷Rb1的相对校正因子，并进行含量计算，实现一测多评；同时采用外标法验证一测多评法的准确性。实验结果显示校正因子重现性好，采用校正因子计算的含量值和外标法实测值之间没有显著性差异。故采用一测多评法同时测定复方血栓通胶囊中4个有效成分的含量，具有准确、简便、经济实用等优点，值得推广。
위건립복방혈전통효낭중4개유효성분적일측다평정량방법，채용고효액상색보법，이인삼조감Rg 1위삼조대조품，계산기여삼칠조감R1、인삼조감Re、인삼조감Rb1적상대교정인자，병진행함량계산，실현일측다평；동시채용외표법험증일측다평법적준학성。실험결과현시교정인자중현성호，채용교정인자계산적함량치화외표법실측치지간몰유현저성차이。고채용일측다평법동시측정복방혈전통효낭중4개유효성분적함량，구유준학、간편、경제실용등우점，치득추엄。
The paper reported the establishment of a quantitative method for simultaneously determining four effective components in Compound Xueshuantong capsule by using one chemical reference,the new quality evaluation method,quantitative analysis of multi-components by single marker (QAMS),using Ginsenoside Rg1 as the internal reference substance,was developed by HPLC to simultaneously determine Notoginsenoside R1 ,Ginsenoside Rg1 ,Ginsenoside Re,Ginsenoside Rb1 in Compound Xueshuantong capsule with the relative correction factor (RCF).In addition,the results of QAMS method were valida-ted by comparing with that of external standard method.The results show that the RCFs have good repro-ducibility and no significant differences between the quantitative results of QAMS method and external standard method were observed.So,it is a accurate,convenient and practical method to simultaneously determine four effective components in Compound Xueshuantong capsule for its quality control.