CAJ | 학술논문

目的：了解代谢综合征及其组分对骨密度的影响。方法2009年11月至2010年2月贵阳市居民健康横断面调查的1512名20～79岁调查对象（男性636名，女性876名）纳入本研究，受试者平均年龄（45.3±14.4）岁。对所有受试者进行问卷调查及体格检查，用OLYMPUS AU5400全自动生化分析仪检测空腹静脉血糖及餐后2 h血糖、三酰甘油、高密度脂蛋白胆固醇、血钙、血磷、血肌酐及血尿酸，用ROCHE 化学发光法测定血清胰岛素；用双能X线检测股骨颈、全髋、 Wards三角、粗隆及腰椎正位（ L1-4）骨密度。结果完成血脂、尿酸、血糖、血钙、血磷、血肌酐、血胰岛素及骨密度检测者1216名，发现代谢综合征患者356例，患病率为29.3％，其中男性125例（35.1％），女性231例（64.9％）；代谢综合征组骨折患病率为5.1％，非代谢综合征组为3.3％；代谢综合征患者全髋及粗隆骨密度较非代谢综合征者高[（0.95±0.15） g/cm2比（0.93±0.14） g/cm2；（0.76±0.13） g/cm2比（0.73±0.12） g/cm2；均P＜0.01]；校正性别及年龄后，股骨颈、全髋、 Wards三角、粗隆及L1-4骨密度值均随代谢综合征患者组份增加而增高（均P＜0.01）。结论代谢综合征患者有较高的全髋及粗隆骨密度，但其骨折率亦较高。
목적：료해대사종합정급기조분대골밀도적영향。방법2009년11월지2010년2월귀양시거민건강횡단면조사적1512명20～79세조사대상（남성636명，녀성876명）납입본연구，수시자평균년령（45.3±14.4）세。대소유수시자진행문권조사급체격검사，용OLYMPUS AU5400전자동생화분석의검측공복정맥혈당급찬후2 h혈당、삼선감유、고밀도지단백담고순、혈개、혈린、혈기항급혈뇨산，용ROCHE 화학발광법측정혈청이도소；용쌍능X선검측고골경、전관、 Wards삼각、조륭급요추정위（ L1-4）골밀도。결과완성혈지、뇨산、혈당、혈개、혈린、혈기항、혈이도소급골밀도검측자1216명，발현대사종합정환자356례，환병솔위29.3％，기중남성125례（35.1％），녀성231례（64.9％）；대사종합정조골절환병솔위5.1％，비대사종합정조위3.3％；대사종합정환자전관급조륭골밀도교비대사종합정자고[（0.95±0.15） g/cm2비（0.93±0.14） g/cm2；（0.76±0.13） g/cm2비（0.73±0.12） g/cm2；균P＜0.01]；교정성별급년령후，고골경、전관、 Wards삼각、조륭급L1-4골밀도치균수대사종합정환자조빈증가이증고（균P＜0.01）。결론대사종합정환자유교고적전관급조륭골밀도，단기골절솔역교고。
Objective The aim of the study is to assess the impact of metabolic syndrome ( MS) and its multi-component on bone mineral density (BMD).Methods We conducted a cross-sectional evaluation of 1512 participants in the general community from November 2009 to February 2010 Guiyang Health Measures Survey .The mean age was 45.3 ± 14.4years.All the subjects underwent questionnaire , anthropometric measurements , blood biochemical analyses .Fasting plasma glucose, 2-hour plasma glucose, serum triglycerides, high density lipoprotein cholesterol, insulin, calcium, phos-phorus , creatinine and uric acid were measured by automatic biochemical analyzer ( OLYMPUS AU5400 ) .Plasma insulin were measured by Chemiluminescence method (ROCHE).The BMD (g/cm2) of the femoral neck, Wards, trochanter, total hip and lumbar spine ( L1-4 ) were measured using a lunar prodigy scanner [ GE Medicail System ( China ) Co. Ltd].Results The prevalence of MS was 29.3% (356 person) of the complete data objectives (1 216 person), within 125 male (35.1%) and 231 female (64.9%), respectively.The prevalence of fracture in MS was higher than Non-MS slightly (5.1%in comparison with 3.3%). In comparison with Non-MS, all BMD values were higher in the MS groups , although only significantly different for total hip and femoral trochanter ( P<0.01 ) , After age and gender ad-justed, a gradual increase of mean levels BMD of all sits was seen when the components of MS was from one up to five ( P<0.01 ) .Conclusion Our study suggests that the MS group represented a higher BMD of total hip and femoral tro -chanter, while also indicated a higher fracture rate than Non-MS group.