CAJ | 학술논문

背景：在钛基体表面涂覆羟基磷灰石涂层能改善钛表面生物活性，诱导骨生长，但纯羟基磷灰石力学性能较差，易在生理环境中降解，影响种植体的稳定性。 　　目的：研究掺镧羟基磷灰石涂层的合成方法及其性能表征。 　　方法：采用溶胶-凝胶法制备纯羟基磷灰石和掺镧质量分数10%，20%，30%的掺镧羟基磷灰石，通过浸渍-提拉法在钛基体上制备纯羟基磷灰石涂层与掺镧羟基磷灰石涂层。扫描电镜观察掺镧羟基磷灰石涂层的形貌和晶粒微观结构，X射线衍射和傅里叶红外光谱分析其基团结构，原子吸收光谱测定Ca2+浓度来分析涂层的降解性能。结果与结论：随着掺镧量的增加，羟基磷灰石衍射峰更强，结晶度更高，但对羟基磷灰石的整体结构影响较小，可维持晶体结构的稳定和电荷平衡。掺镧羟基磷灰石涂层均匀致密，与钛基底结合紧密，两者之间虽有可见的界面，但没有明显缝隙和裂纹，提示涂层具有较好的结合强度。通过模拟生物环境测定释放的钙离子得出掺镧羟基磷灰石抗酸性更强。
배경：재태기체표면도복간기린회석도층능개선태표면생물활성，유도골생장，단순간기린회석역학성능교차，역재생리배경중강해，영향충식체적은정성。 　　목적：연구참란간기린회석도층적합성방법급기성능표정。 　　방법：채용용효-응효법제비순간기린회석화참란질량분수10%，20%，30%적참란간기린회석，통과침지-제랍법재태기체상제비순간기린회석도층여참란간기린회석도층。소묘전경관찰참란간기린회석도층적형모화정립미관결구，X사선연사화부리협홍외광보분석기기단결구，원자흡수광보측정Ca2+농도래분석도층적강해성능。결과여결론：수착참란량적증가，간기린회석연사봉경강，결정도경고，단대간기린회석적정체결구영향교소，가유지정체결구적은정화전하평형。참란간기린회석도층균균치밀，여태기저결합긴밀，량자지간수유가견적계면，단몰유명현봉극화렬문，제시도층구유교호적결합강도。통과모의생물배경측정석방적개리자득출참란간기린회석항산성경강。
BACKGROUND:Hydroxyapatite-coated titanium substrates improve the biocompatibility and have the property of intimating ossteointegration with host bonebed. However, hydroxyapatite lacks the necessary mechanical strength and degrades easily in the extracelular fluids, which may affect the stability of the titanium implant. OBJECTIVE:To study the synthesis and characterization of lanthanum-incorporated hydroxyapatite coatings. METHODS: Lanthanum-incorporated hydroxyapatite coatings were prepared by hydroxyapatite and 10%, 20% and 30% lanthanum, respectively, by means of sol-gel, which were then deposited on titanium substrates with dip-withdrawal technique. Surface morphology and crystaline microstructure of the coatings were observed by scanning electron microscope. The presence of functional groups for the obtained samples was performed by Fourier transform infrared absorption spectroscopy and X-ray diffraction. The Ca2+ concentration released from the coatings was measured by atomic absorption spectrometry for analysis of degradation property. RESULTS AND CONCLUSION: With the increase of lanthanum content, the diffraction peak and crystalinity of lanthanum-incorporated hydroxyapatite coatings were increased, but the whole structure of lanthanum-incorporated hydroxyapatites had little changes. The crystal structure maintained stable with charge balance. The lanthanum-incorporated hydroxyapatite coatings showed uniform and high-dense structure and were free of cracks, indicating the coatings had good bonding strength. Under the simulated biological environment, based on the determination of Ca2+ release from the coatings, we can conclude the lanthanum-incorporated hydroxyapatite coatings have a stronger acidoresistance.