CAJ | 학술논문

背景：随着组织工程技术的发展，多孔生物陶瓷被越来越多的运用到骨缺损的修复中，当前的研究主要集中在这种生物陶瓷的合成及其各项性能的评价。 　　目的：研究一种新型骨水泥的制备方法并测定其理化性能及与成骨细胞的生物相容性。 　　方法：共沉淀法制备双相钙磷生物陶瓷粉体，利用胶体团聚成颗粒，烧结后得到颗粒状、多孔羟基磷灰石/磷酸三钙生物陶瓷，并按不同比例与高纯度医用半水硫酸钙混合制备钙磷陶瓷/硫酸钙骨水泥。 　　结果与结论：X 射线衍射证实合成物质为双相钙磷陶瓷，颗粒状双相钙磷陶瓷具有多孔网状结构，骨水泥在3 min内保持可塑状态，固化时间为15 min，固化温度为36.5℃，压缩强度最高为5.82 MPa，MTT毒性级为0级，成骨细胞在材料表面生长良好。
배경：수착조직공정기술적발전，다공생물도자피월래월다적운용도골결손적수복중，당전적연구주요집중재저충생물도자적합성급기각항성능적평개。 　　목적：연구일충신형골수니적제비방법병측정기이화성능급여성골세포적생물상용성。 　　방법：공침정법제비쌍상개린생물도자분체，이용효체단취성과립，소결후득도과립상、다공간기린회석/린산삼개생물도자，병안불동비례여고순도의용반수류산개혼합제비개린도자/류산개골수니。 　　결과여결론：X 사선연사증실합성물질위쌍상개린도자，과립상쌍상개린도자구유다공망상결구，골수니재3 min내보지가소상태，고화시간위15 min，고화온도위36.5℃，압축강도최고위5.82 MPa，MTT독성급위0급，성골세포재재료표면생장량호。
BACKGROUND:With the development of tissue engineering, porous bioceramics are more and more used to repair bone defects. Current research focuses on the biological synthesis of this bioceramics and its performance evaluation. OBJECTIVE:To discuss the preparation of a new kind of bone cement and to determine its physicochemical properties and biocompatibility with osteoblasts. METHODS:Biphasic tricalcium phosphate powders were prepared using co-precipitation method. The powder was turned into granular stuff by arabic gum. After sintering, porous hydroxyapatite/tricalcium phosphate bioceramics were harvested, and then mixed with alpha-hemihydrate to prepare the bone cement. RESULTS AND CONCLUSION:X-ray diffraction confirmed that the synthetic substance was a kind of biphasic calcium phosphate ceramic having a porous structure. The bone cement could be in the plastic state within 3 minutes. The curing time was 15 minutes, and the curing temperature was 36.5℃. The maximum compression strength was 5.82 MPa, and the MTT toxicity was level 0. Osteoblasts could grew wel on the material surface.