医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
28期
170-171
,共2页
氨酚羟考酮%开胸术%术后镇痛
氨酚羥攷酮%開胸術%術後鎮痛
안분간고동%개흉술%술후진통
oxycodone-acetaminophen tablet%thoracotomy%postoperative analgesics
目的评价不同剂量氨酚羟考酮片在开胸术后病人中的镇痛疗效。方法选择107例接受开胸手术,并且术后可以进食的病人,随机分为氨酚羟考酮10mg组和5mg组,均维持镇痛3天,并肌注哌替啶50mg/次作为补救镇痛。观察并记录术后1h、6h、12h、24h、48h、72h的VAS评分、补救镇痛率以及药物不良反应。结果两组病人术后1h的 VAS评分比较差异无统计学意义(P>0.05)。随静脉麻醉作用消退,10mg组术后6h、12h、24h各时点VAS评分均低于5mg组(P<0.05),至术后48h、72h,两组VAS评分比较差异无统计学意义(P>0.05)。10mg组补救镇痛率低于5mg组(P<0.05),不良反应发生率与5mg组无统计学差异(P>0.05)。结论10mg氨酚羟考酮用于开胸病人术后镇痛效果良好,既能减少补救镇痛药物使用,又不增加药物不良反应,建议术后早期使用10mg以迅速缓解疼痛,之后减量至5mg。
目的評價不同劑量氨酚羥攷酮片在開胸術後病人中的鎮痛療效。方法選擇107例接受開胸手術,併且術後可以進食的病人,隨機分為氨酚羥攷酮10mg組和5mg組,均維持鎮痛3天,併肌註哌替啶50mg/次作為補救鎮痛。觀察併記錄術後1h、6h、12h、24h、48h、72h的VAS評分、補救鎮痛率以及藥物不良反應。結果兩組病人術後1h的 VAS評分比較差異無統計學意義(P>0.05)。隨靜脈痳醉作用消退,10mg組術後6h、12h、24h各時點VAS評分均低于5mg組(P<0.05),至術後48h、72h,兩組VAS評分比較差異無統計學意義(P>0.05)。10mg組補救鎮痛率低于5mg組(P<0.05),不良反應髮生率與5mg組無統計學差異(P>0.05)。結論10mg氨酚羥攷酮用于開胸病人術後鎮痛效果良好,既能減少補救鎮痛藥物使用,又不增加藥物不良反應,建議術後早期使用10mg以迅速緩解疼痛,之後減量至5mg。
목적평개불동제량안분간고동편재개흉술후병인중적진통료효。방법선택107례접수개흉수술,병차술후가이진식적병인,수궤분위안분간고동10mg조화5mg조,균유지진통3천,병기주고체정50mg/차작위보구진통。관찰병기록술후1h、6h、12h、24h、48h、72h적VAS평분、보구진통솔이급약물불량반응。결과량조병인술후1h적 VAS평분비교차이무통계학의의(P>0.05)。수정맥마취작용소퇴,10mg조술후6h、12h、24h각시점VAS평분균저우5mg조(P<0.05),지술후48h、72h,량조VAS평분비교차이무통계학의의(P>0.05)。10mg조보구진통솔저우5mg조(P<0.05),불량반응발생솔여5mg조무통계학차이(P>0.05)。결론10mg안분간고동용우개흉병인술후진통효과량호,기능감소보구진통약물사용,우불증가약물불량반응,건의술후조기사용10mg이신속완해동통,지후감량지5mg。
Objective To observe the analgesic efficacy of two different dosages of oxycodone acetaminophen tablet used after thoracotomy. Methods One hundred and seven patients after thoracotomy were randomly divided into two groups, taking oxycodone acetaminophen tablet l0mg q8h or 5mg q8h, respectively. The pain score by VAS, use of rescue pethidine hydrochloride, side effect were recorded and compared between the two groups. Results There is no significant difference in scores of pain between the two groups at 1h, 48h, 72h after surgery(P>0.05). However, scores of pain in 10mg group were lower than those in 5mg group at 6h, 12h, 24h after surgery(P<0.05). The use rate of rescue pethidine in 10mg group was lower than in 5mg group(P<0.05). There is no significant difference in the incidence of side effects between the two groups(P>0.05). Conclusion 10mg oxycodone-acetaminophen is superior to 5mg in relieving pain, reducing use of rescue pethidine, without increasing side effects. 10mg early, then 5mg after surgery is recommended.