CAJ | 학술논문

青霉素是常见的β－内酰胺类抗生素，对人体毒性很低，由发酵液提取获得。在我国一般采用分批发酵法来生产青霉素，此法耗时长、设备昂贵、人工成本高、流程复杂、产品质控难，难以满足现代工业的发展需求。本文通过对现有生产工艺的探讨，对其进行改进，为青霉素生产工业设计了一套崭新的连续发酵工艺。
청매소시상견적β－내선알류항생소，대인체독성흔저，유발효액제취획득。재아국일반채용분비발효법래생산청매소，차법모시장、설비앙귀、인공성본고、류정복잡、산품질공난，난이만족현대공업적발전수구。본문통과대현유생산공예적탐토，대기진행개진，위청매소생산공업설계료일투참신적련속발효공예。
Penicillin is one kind of most common and low toxic β-lactam antibiotic, mainly attained by the fermentation fluid. In our country, it is often produced by fedbatch fermentation, which is timeconsuming, with characteristics such as high costs, laborintensive, complicated process, unstable quality, and can not satisfy the need of modern industrialization. Ac cording to the analysis on the existing process, this article designed a novel process of continuous fermentation for penicillin production.