医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
28期
131-132
,共2页
类风湿因子%免疫比浊法%肌钙蛋白I%假阳性
類風濕因子%免疫比濁法%肌鈣蛋白I%假暘性
류풍습인자%면역비탁법%기개단백I%가양성
Rheumatoid factor%Immunonephelometry%Troponin I%False positive
目的探讨类风湿因子对免疫比浊法测定肌钙蛋白I产生的干扰性假阳性及对策。方法选取类风湿因子在0-55IU/mL、56-109IU/ mL、110IU/mL以上的患者标本各20例，且都无慢性支气管炎、肺心病、冠心病等器质性疾病，CK、CK-MB、AST、肌红蛋白（MYO）均正常、无黄胆及高脂血症的患者标本，用免疫比浊法测定肌钙蛋白I和电化学发光法测定肌钙蛋白T，分析类风湿因子对测定的干扰作用。结果类风湿因子在0-55 IU/mL时对肌钙蛋白I未造成干扰，在56-109IU/mL时可造成轻度干扰，在超过110IU/mL时可造成明显干扰。结论明显增高的类风湿因子会引起免疫比浊法测定肌钙蛋白I出现假阳性，通过联合和连续监测CK、CK-MB、AST、肌红蛋白（MYO）以及分析临床资料，可以识别这种假阳性，以避免对临床诊治造成干扰。
目的探討類風濕因子對免疫比濁法測定肌鈣蛋白I產生的榦擾性假暘性及對策。方法選取類風濕因子在0-55IU/mL、56-109IU/ mL、110IU/mL以上的患者標本各20例，且都無慢性支氣管炎、肺心病、冠心病等器質性疾病，CK、CK-MB、AST、肌紅蛋白（MYO）均正常、無黃膽及高脂血癥的患者標本，用免疫比濁法測定肌鈣蛋白I和電化學髮光法測定肌鈣蛋白T，分析類風濕因子對測定的榦擾作用。結果類風濕因子在0-55 IU/mL時對肌鈣蛋白I未造成榦擾，在56-109IU/mL時可造成輕度榦擾，在超過110IU/mL時可造成明顯榦擾。結論明顯增高的類風濕因子會引起免疫比濁法測定肌鈣蛋白I齣現假暘性，通過聯閤和連續鑑測CK、CK-MB、AST、肌紅蛋白（MYO）以及分析臨床資料，可以識彆這種假暘性，以避免對臨床診治造成榦擾。
목적탐토류풍습인자대면역비탁법측정기개단백I산생적간우성가양성급대책。방법선취류풍습인자재0-55IU/mL、56-109IU/ mL、110IU/mL이상적환자표본각20례，차도무만성지기관염、폐심병、관심병등기질성질병，CK、CK-MB、AST、기홍단백（MYO）균정상、무황담급고지혈증적환자표본，용면역비탁법측정기개단백I화전화학발광법측정기개단백T，분석류풍습인자대측정적간우작용。결과류풍습인자재0-55 IU/mL시대기개단백I미조성간우，재56-109IU/mL시가조성경도간우，재초과110IU/mL시가조성명현간우。결론명현증고적류풍습인자회인기면역비탁법측정기개단백I출현가양성，통과연합화련속감측CK、CK-MB、AST、기홍단백（MYO）이급분석림상자료，가이식별저충가양성，이피면대림상진치조성간우。
Objective To investigate the rheumatoid factor immune turbidimetric method to determine troponin I produced false-positive interference and countermeasures. Method Selects of rheumatoid factor in 0-55IU/mL ,56-109IU / mL, 110IU/mL with more than 20 cases specimens of patients, and no chronic bronchitis, Cor pulmonale , coronary artery heart disease and other organic diseases. CK, CK-MB, AST, myoglobin (MYO) were normal, no jaundice and Hyperlipidemia in patients with specimens with immunoturbidimetric determination of troponin I and electrochemiluminescence determination of troponin T, analysis of rheumatoid factor on the determination of the interference effect. Results When the results of rheumatoid factor in the 0-55 IU / mL for Troponin I, no interference, in 56-109IU/mL can cause mild interference, more than 110IU/mL can cause significant interference. Conclusion Significantly higher rheumatoid factor causes the immune turbidimetric method false positive troponin I, and continuous monitoring by the Joint CK, CK-MB, AST, myoglobin (MYO), and analysis of clinical data, can identify the false positive, clinical diagnosis and treatment in order to avoid causing interference.
