中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
7期
605-608
,共4页
胡楠楠%傅松年%王江涛%党海红
鬍楠楠%傅鬆年%王江濤%黨海紅
호남남%부송년%왕강도%당해홍
抑郁障碍%IL-1β%基因多态性%维吾尔族
抑鬱障礙%IL-1β%基因多態性%維吾爾族
억욱장애%IL-1β%기인다태성%유오이족
Depressive disorders%Interleukin-1 Beta%Single nucleotide polymorphism%Uygur
目的 探讨白介素-1β(IL-1β)基因-511C/T和-31T/C多态性与新疆维吾尔族人群抑郁障碍的相关性.方法 采用聚合酶链反应-限制性片段长度多态性方法对目的片段进行扩增,用限制性内切酶酶切消化反应方法对目的片段进行基因分型.研究选取100例维族抑郁障碍患者和120名维族健康受试者,对IL-1β基因启动子区-511C/T和-31T/C位点进行多态性分析.结果 IL-1β基因启动子区-511 C/T在病例组和健康对照组中基因型频率分别为:CC型19％和19.2％,CT型58％和55％,TT型23％和25.8％.-511C/T抑郁障碍组与对照组基因频率相似,差异无统计学意义(x2=0.266,P=0.875).-31T/C在病例组和健康对照组中基因型频率分别为:CC型24％和24.2％,CT型58％和58.3％,TT型18％和17.5％.-31T/C抑郁障碍与对照组基因频率相似,差异无统计学意义(x2=0.0093,P=0.995).结论 IL-1β基因启动子区-511C/T和-31T/C基因多态性和新疆维吾尔族抑郁障碍的发生无明显相关性.
目的 探討白介素-1β(IL-1β)基因-511C/T和-31T/C多態性與新疆維吾爾族人群抑鬱障礙的相關性.方法 採用聚閤酶鏈反應-限製性片段長度多態性方法對目的片段進行擴增,用限製性內切酶酶切消化反應方法對目的片段進行基因分型.研究選取100例維族抑鬱障礙患者和120名維族健康受試者,對IL-1β基因啟動子區-511C/T和-31T/C位點進行多態性分析.結果 IL-1β基因啟動子區-511 C/T在病例組和健康對照組中基因型頻率分彆為:CC型19％和19.2％,CT型58％和55％,TT型23％和25.8％.-511C/T抑鬱障礙組與對照組基因頻率相似,差異無統計學意義(x2=0.266,P=0.875).-31T/C在病例組和健康對照組中基因型頻率分彆為:CC型24％和24.2％,CT型58％和58.3％,TT型18％和17.5％.-31T/C抑鬱障礙與對照組基因頻率相似,差異無統計學意義(x2=0.0093,P=0.995).結論 IL-1β基因啟動子區-511C/T和-31T/C基因多態性和新疆維吾爾族抑鬱障礙的髮生無明顯相關性.
목적 탐토백개소-1β(IL-1β)기인-511C/T화-31T/C다태성여신강유오이족인군억욱장애적상관성.방법 채용취합매련반응-한제성편단장도다태성방법대목적편단진행확증,용한제성내절매매절소화반응방법대목적편단진행기인분형.연구선취100례유족억욱장애환자화120명유족건강수시자,대IL-1β기인계동자구-511C/T화-31T/C위점진행다태성분석.결과 IL-1β기인계동자구-511 C/T재병례조화건강대조조중기인형빈솔분별위:CC형19％화19.2％,CT형58％화55％,TT형23％화25.8％.-511C/T억욱장애조여대조조기인빈솔상사,차이무통계학의의(x2=0.266,P=0.875).-31T/C재병례조화건강대조조중기인형빈솔분별위:CC형24％화24.2％,CT형58％화58.3％,TT형18％화17.5％.-31T/C억욱장애여대조조기인빈솔상사,차이무통계학의의(x2=0.0093,P=0.995).결론 IL-1β기인계동자구-511C/T화-31T/C기인다태성화신강유오이족억욱장애적발생무명현상관성.
Objective To explore the distribution on-511C/T,-31T/C single nucleotide polymorphism of IL-1β gene among Uygur population in Xinjiang,and to analyze the correlation between IL-1β gene polymorphism and depressive disorders.Methods A total of 100 patients with depressive disorders and 120 control subjects were selected.Polymerase chain reaction and restriction fragment length polymorphism (RFLP-PCR),enzyme digestion and sequence reaction were used to detect the common-511C/T,-31T/C polymorphism of the IL-1β gene.The relationship between the polymorphism in the IL-1β gene and the severity of depressive disorders was analyzed.Results The frequencies of CC,CT,TT in-511 were 19.0％,58.0％ and 23.0％ in patient group,while those were 19.2％,55.0％,25.8％ in the control group,which did not show statistically significant differences (x2=0.266,P=0.875).The frequencies of CC,CT,TT in-31 were 24.0％,58.0％ and 18.0％ in the patient group,while those were 24.2％,58.3％,17.5％ in the control group,which did not show statistically significant differences (x2=0.0093,P=0.995).The frequencies of CC,CT,TT genotypes of the IL-1β gene polymorphism (-511 C/T,-31 T/C) were not statistically different between depressive patients and healthy controls.Conclusion The findings suggest no significant association between-511C/T,-31T/C polymorphism and depressive disorders in Uygur population of Xinjiang.
